• Vestergaard, Jesper Medom
• Christensen, Mette Skovgaard
• Schlünssen, Vivi
• Stokholm, Zara Ann
• Kolstad, Henrik Albert
• Iversen, Inge Brosbøl
• Nissen, Mette Schou

Abstract

<p>Sinonasal adenocarcinoma is a rare disease expected to have rare causes and potential for strong risk factors as reflected by the strong link with occupational wood dust exposure. pecifically, high level styrene exposure is a rare and suspected carcinogen. The exposure–response relation between occupational styrene exposure, sinonasal adenocarcinoma, and other subtypes was examined. This study followed 73,092 styrene-exposed workers from 1968 to 2011 and identified sinonasal cancers in the Danish Cancer Registry. Cumulative styrene exposure and estimated incidence rates and age, sex, and wood-industry adjusted OR were modeled. During 1,585,772 person-years, nine cases of adenocarcinoma were observed corresponding to a five-fold non-significantly increased OR for estimates of high versus low cumulative styrene exposure. The increased risk was confined to exposure received during the recent 15 yr. The other histological subtypes showed no increased risk.</p>

Topics

• impedance spectroscopy
• polymer
• wood