| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Sharma, Prashant K.
University Medical Center Groningen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2023Modulating the water behavior, microstructure, and viscoelasticity of plasma-derived hydrogels by adding silica nanoparticles with tailored chemical and colloidal propertiescitations
- 2022Viscoelastic properties of plasma-agarose hydrogels dictate favorable fibroblast responses for skin tissue engineering applicationscitations
- 2021Chemical and mechanical influence of root canal irrigation on biofilm removal from lateral morphological features of simulated root canals, dentine discs and dentinal tubulescitations
- 2019Chemical biofilm removal capacity of endodontic irrigants as a function of biofilm structurecitations
- 2019Chemical efficacy of several NaOCl concentrations on biofilms of different architecturecitations
- 2019Factors affecting the chemical efficacy of 2% sodium hypochlorite against oral steady-state dual-species biofilmscitations
- 2018Notochordal cell matrix as a bioactive lubricant for the osteoarthritic jointcitations
- 2017Implant Failurecitations
- 2013Stress relaxation analysis facilitates a quantitative approach towards antimicrobial penetration into biofilmscitations
- 2013A Distinguishable Role of eDNA in the Viscoelastic Relaxation of Biofilmscitations
- 2009Tunable Visible Emission of Ag-Doped CdZnS Alloy Quantum Dots
- 2009Bacterial Adhesion to Diamond-like Carbon as Compared to Stainless Steelcitations
- 2009Hyphal content determines the compression strength of Candida albicans biofilmscitations
- 2008Physicochemical and microbial fouling characterization of novel, extremely hydrophobic, nanocomposite diamond like carbon polymer hybrid coatings
- 2007Low-load compression testingcitations
- 2007Low-load compression testing:a novel way of measuring biofilm thicknesscitations
- 2001Surface chemical characterisation of Paenibacillus polymyxa before and after adaptation to sulfide mineralscitations
Places of action
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article
A Distinguishable Role of eDNA in the Viscoelastic Relaxation of Biofilms
Abstract
Bacteria in the biofilm mode of growth are protected against chemical and mechanical stresses. Biofilms are composed, for the most part, of extracellular polymeric substances (EPSs). The extracellular matrix is composed of different chemical constituents, such as proteins, polysaccharides, and extracellular DNA (eDNA). Here we aimed to identify the roles of different matrix constituents in the viscoelastic response of biofilms. Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, and Pseudomonas aeruginosa biofilms were grown under different conditions yielding distinct matrix chemistries. Next, biofilms were subjected to mechanical deformation and stress relaxation was monitored over time. A Maxwell model possessing an average of four elements for an individual biofilm was used to fit the data. Maxwell elements were defined by a relaxation time constant and their relative importance. Relaxation time constants varied widely over the 104 biofilms included and were divided into seven ranges (500 s). Principal-component analysis was carried out to eliminate related time constant ranges, yielding three principal components that could be related to the known matrix chemistries. The fastest relaxation component ( IMPORTANCE The protection offered by biofilms to organisms that inhabit it against chemical and mechanical stresses is due in part to its matrix of extracellular polymeric substances (EPSs) in which biofilm organisms embed themselves. Mechanical stresses lead to deformation and possible detachment of biofilm organisms, and hence, rearrangement processes occur in a biofilm to relieve it from these stresses. Maxwell analysis of stress relaxation allows the determination of characteristic relaxation time constants, but the biofilm components and matrix constituents associated with different stress relaxation processes have never been identified. Here we grew biofilms with different matrix constituents and used principal-component analysis to reveal that the presence of water and soluble ...