| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zhang, Chi
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024Nanostructure and interfacial mechanical properties of PEG/cellulose nanocomposites studied with molecular dynamicscitations
- 2024Anisotropic Deformation in a Polymer Slab Subjected to Fluid Adsorptioncitations
- 2023Phytic Acid-Silica System for Imparting Fire Retardancy in Wood Compositescitations
- 2022Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactionscitations
- 2022Growth-microstructure-thermal property relations in AlN thin filmscitations
- 2022Unravelling thermal-mechanical effects on microstructure evolution under superplastic forming conditions in a near alpha titanium alloycitations
- 2020Moisture-induced crossover in the thermodynamic and mechanical response of hydrophilic biopolymercitations
- 2020Disentangling heat and moisture effects on biopolymer mechanicscitations
- 2019Wood–moisture relationships studied with molecular simulations: methodological guidelinescitations
- 2018Quadratic and cubic hyperpolarizabilities of nitro-phenyl/-naphthalenyl/-anthracenyl alkynyl complexescitations
- 2018Using modeling to understand the hygromechanical and hysteretic behavior of the S2 cell wall layer of woodcitations
- 2015Syntheses, Electrochemical, Linear Optical, and Cubic Nonlinear Optical Properties of Ruthenium-Alkynyl-Functionalized Oligo(phenylenevinylene) Starscitations
- 2015Pressure, stress, and strain distribution in the double-stage diamond anvil cellcitations
- 2010Highly sensitive bend sensor based on Bragg grating in eccentric core polymer fibercitations
- 2007Recent developments of Bragg gratings in PMMA and TOPAS polymer optical fibers
- 2007Recent developments of Bragg gratings in PMMA and TOPAS polymer optical fibers
Places of action
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article
Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions
Abstract
<jats:p>Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of the protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved under positive selection and has undergone repeated genomic duplications in bats in contrast to all studied mammals that have a single copy of the gene. Functional testing of the relationship between PKR and poxvirus antagonists revealed how an evolutionary conflict with ancient pathogenic poxviruses has shaped a specific bat host-virus interface. We determined that duplicated PKRs of the<jats:italic>Myotis</jats:italic>species have undergone genetic diversification, allowing them to collectively escape from and enhance the control of DNA and RNA viruses. These findings suggest that viral-driven adaptations in PKR contribute to modern virus-bat interactions and may account for bat-specific immunity.</jats:p>