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Lee, Byeong Ha
in Cooperation with on an Cooperation-Score of 37%
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Publications (5/5 displayed)
- 2018Analysis of design and fabrication parameters for lensed optical fibers as pertinent probes for sensing and imagingcitations
- 2016Photoacoustic microscopy based on polydimethylsiloxane thin film Fabry-Perot optical interferometer
- 2015Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometrycitations
- 2015Photoacoustic signal measurement using thin film Fabry-Perot optical interferometer for photoacoustic microscopycitations
- 2008Observation of tunable bandpass characteristics in a hollow-optical-fiber-microstructured-fiber composite structure using bend-loss edge-shift effectscitations
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article
Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometry
Abstract
We present three-dimensional (3-D) in vivo photoacoustic (PA) images of the blood vasculature of a chicken chorioallantoic membrane (CAM) obtained by using a fiber-based noncontact PA tomography system. With a fiber-optic heterodyne interferometer, the system measures the surface displacement of a sample, induced by the PA wave, which overcomes the disadvantage of physical-contact of ultrasonic transducer in a conventional system. The performance of an implemented system is analyzed and its capability of in vivo 3-D bioimaging is presented. At a depth of 2.5 mm in a phantom experiment, the lateral and axial resolutions were measured as 100 and 30 mu m, respectively. The lateral resolution became doubled at a depth of 7.0 mm; however, interestingly, the axial resolution was not noticeably deteriorated with the depth. With the CAM experiment, performed under the American National Standards Institute laser safety standard condition, blood vessel structures placed as deep as 3.5 mm were clearly recognized. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.