| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rottmar, Markus
Swiss Federal Laboratories for Materials Science and Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2024Amino-acid-specific thiol-ene coupling governs hydrogel crosslinking mechanism and cell behaviorcitations
- 20233D-printed poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-cellulose-based scaffolds for biomedical applicationscitations
- 20233D-Printed Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-Cellulose-Based Scaffolds for Biomedical Applicationscitations
- 2023Surface chemistry dictates the osteogenic and antimicrobial properties of palladium-, platinum-, and titanium-based bulk metallic glassescitations
- 2022Multiscale 2D/3D microshaping and property tuning of polymer-derived SiCN ceramicscitations
- 2022Palladium-based metallic glass with high thrombogenic resistance for blood-contacting medical devicescitations
- 2021Nano‐3D‐printed photochromic micro‐objectscitations
- 2020In vitro cytocompatibility assessment of Ti-modified silicon-oxycarbide based polymer-derived ceramic implantable electrodes under pacing conditionscitations
- 2020Responsive Nanofibers with Embedded Hierarchical Lipid Self-Assembliescitations
- 2019Mussel-inspired injectable hydrogel adhesive formed under mild conditions features near-native tissue propertiescitations
- 2018Controlling the surface structure of electrospun fibers: effect on endothelial cells and blood coagulationcitations
- 2016A bioinspired ultraporous nanofiber-hydrogel mimic of the cartilage extracellular matrixcitations
Places of action
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article
Controlling the surface structure of electrospun fibers: effect on endothelial cells and blood coagulation
Abstract
The influence of nano- or micron-sized structures on polymer films as well as the impact of fiber diameter of electrospun membranes on endothelial cell (EC) and blood response has been studied for vascular tissue engineering applications. However, the influence of surface structures on micronsized fibers on endothelial cells and blood interaction is currently not known. In this work, electrospun membranes with distinct fiber surface structures were designed to study their influence on the endothelial cell viability and thrombogenicity. The thermodynamically derived Hansen-solubilityparameters model accurately predicted the formation of solvent dependent fiber surface structured poly(caprolactone) membranes. The electrospun membranes composed of microfibers (MF) or structured MF were of similar fiber diameter, macroscopic roughness, wettability, and elastic modulus. In vitro evaluation with ECs demonstrated that cell proliferation and morphology were not affected by the fiber surface structure. Similarly, investigating the blood response to the fiber meshes showed comparable fibrin network formation and platelet activation on MF and structured MF. Even though the presented results provide evidence that surface structures on MF appear neither to affect EC viability nor blood coagulation, they shed light on the complexity and challenges when studying biology-material interactions. They thereby contribute to the understanding of EC and blood-material interaction on electrospun membranes.