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Mohammed, Afzal R.
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Publications (2/2 displayed)
- 2017Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tabletscitations
- 2013Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersionscitations
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article
Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets
Abstract
<b>Objectives:</b> The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs).<br></br><br></br><b>Methods:</b> The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macro-property assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing.<br></br><br></br><b>Key findings:</b> The results showed that MCC demonstrated its best flowability at a moisture content of 11.2% w/w when compared to control, comprising of3.9% w/w moisture. The use of the composite powder coating process (without air) resulted in up to 80% increase in tablet hardness, when compared to the control. The study also demonstrated that surface adsorbed moisture can be displaced upon addition of excipients during dry processing circumventing the need for particle drying before tabletting.<br></br><br></br><b>Conclusions:</b> It was concluded that MCC with a moisture content of 11% w/w provides a good balance between powder flowability and favourable ODT characteristics.