| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Søballe, Kjeld
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2015The Influence of Hemostatic Agents on Bone Healing After Sternotomy in a Porcine Modelcitations
- 2012Cobalt release from implants and consumer items and characteristics of cobalt sensitized patients with dermatitiscitations
- 2012Acid etching and plasma sterilization fail to improve osseointegration of grit blasted titanium implantscitations
- 2010Acid etching does not improve CoCrMo implant osseointegration in a canine implant model
- 2009Local bisphosphonate treatment increases fixation of hydroxyapatite-coated implants inserted with bone compactioncitations
- 2009Clinical comparison of polyethylene wear with zirconia or cobalt-chromium femoral headscitations
- 2008Bone growth enhancement in vivo on press-fit titanium alloy implants with acid etched microtexturecitations
- 2007Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidney.citations
- 2005In vivo study of the effect of RGD treatment on bone ongrowth on press-fit titanium alloy implantscitations
Places of action
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article
Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidney.
Abstract
Cobalt-chromium-molybdenum (CoCrMo) metal-on-metal hip prosthesis has had a revival due to their excellent wear properties. However, particulate wear debris and metal ions liberated from the CoCrMo alloys might cause carcinogenicity, hypersensitivity, local and general tissue toxicity, genotoxicity and inflammation-generating qualities. Nine months after implanting small pieces of CoCrMo alloy intramuscularly and intraperitoneally in rats, we analysed the accumulation of metals with a multi-element analysis, and the levels of metallothionein I/II with real-time reverse transcriptase-polymerase chain reaction in liver and kidney. We found that metal ions are liberated from CoCrMo alloys and suggest that they are released by dissolucytosis, a process where macrophages causes the metallic surface to release metal ions. Animals with intramuscular implants accumulated metal in liver and kidney and metallohionein I/II were elevated in liver tissue. The present data do not tell whether kidney and liver are the primary target organs or what possible toxicological effect the different metal ions might have, but they show that metal ions are liberated from CoCrMo alloys that are not subjected to mechanical wear and that they accumulate in liver and kidney tissue. That the liberated metal ions affect the tissues is supported by an up-regulation of the detoxifying/pacifying metalloprotein I/II in the liver.<br /> Udgivelsesdato: 2007-Dec