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| Azevedo, Nuno Monteiro |
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Chandiramani, M.
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article
Fetal fibronectin as a predictor of spontaneous preterm labour in asymptomatic women with a cervical cerclage
Abstract
To assess the accuracy of fetal fibronectin (fFN) testing for prediction of preterm labour in asymptomatic high-risk women with a cervical cerclage.Retrospective observational study.United Kingdom.Nine hundred and ten asymptomatic women at high-risk of Preterm birth referred to specialist antenatal clinics and undergoing fFN testing between November 1997 and December 2007.Women had fFN tests taken between 23(+0) and 27(+6) weeks' gestation, on one or more occasions.Sensitivity, specificity, positive predictive values and negative predictive values of fFN testing for predicting delivery <30 and <37 weeks were compared in those with and without cerclage.For delivery <30 weeks' gestation, the specificity of fFN testing was significantly lower in women with cervical cerclage (77% vs 90%; P0.4). The negative predictive value of the fFN test for delivery <30 weeks was high in both groups (> 98%).Asymptomatic high-risk women with cerclage in situ are more likely to have a false positive fFN test. The negative predictive value is similar.