• Turner, Emma
• Metcalfe, Chris
• Martin, Richard
• Neal, De
• Williams, N.
• Hughes, Lj
• Hamdy, Fc
• Donovan, Jenny L.

Abstract

Keywords:PSA testing;screening;primary health care;prostate cancer;socioeconomic differences Study Type – Practice patterns (retrospective cohort) Level of Evidence 2bWhat is known on the subject? and what does the study add?There is no organized screening programme for prostate cancer in the UK, although men can request a PSA test at their general practice. The testing rate had been estimated at 6% per year among 45–84 year old men during 2001 to 2007. Our study estimated the annual practice-based PSA testing rate for men aged 45–89 years with no previous diagnosis of prostate cancer at 6.2% during 2007. This is very similar to the rate found in the earlier study. Older men and men at general practices situated in more affluent areas were found to be most likely to undergo a PSA test, suggesting that uptake of the test is not reflecting clinical need.OBJECTIVE • To estimate rates of prostate-specific antigen (PSA) testing in UK general practices by age, deprivation index and geographical location.SUBJECTS AND METHODS • Practice-based, retrospective data on PSA testing patterns in 2007 were collected from a random sample of 87 general practices using EMIS LV computer systems within the passively observed non-intervention arm of a cluster-randomized controlled trial.• Information for a total of 126 716 men aged 45–89 years with no recorded diagnosis of prostate cancer prior to 1 January 2007 was collected.RESULTS • In all, 7902 (6.2%) of 126 716 men aged 45–89 without a prior diagnosis of prostate cancer underwent at least one PSA test from their general practitioner during 2007 [95% confidence interval (CI) 5.6–7.0%; practice-based inter-quartile range 3.6–8.4%].• PSA testing rates were 1.4% (95% CI 1.1–1.6%) in men aged 45–49, rising to 11.3% (95% CI 10.0–12.9%) at age 75–79 years (P for trend

Topics

• impedance spectroscopy
• cluster
• random
• chemical ionisation