| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Moreno, M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2020Electrochemical Characterization of Cu-Catalysed Si Nanowires as an Anode for Lithium-Ion Cellscitations
- 2019Cu-catalyzed Si-NWS grown on “carbon paper” as anodes for Li-ion cellscitations
- 2019Room temperature ionic liquid (RTIL)-based electrolyte cocktails for safe, high working potential Li-based polymer batteriescitations
- 2019Room temperature ionic liquid (RTIL)-based electrolyte cocktails for safe, high working potential Li-based polymer batteriescitations
- 2018A highly sensitive microsystem based on nanomechanical biosensors for genomics applicationscitations
- 2017Towards High Energy Density Aging Resistant Li-ion Polymer Batteries
- 2016New Insights Towards Aging Resistant Li-ion Polymer Batteries For Wide Temperature Applications
- 2016Cadmium Sulfide Thin Films Deposited onto MWCNT/Polysulfone Substrates by Chemical Bath Depositioncitations
- 2015New Insights in Aging Resistant Lithium Polymer Batteries for Highly Stressful Applications
- 2013Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-β treatment.citations
- 2006A highly sensitive microsystem based on nanomechanical biosensors for genomics applicationscitations
- 2005Anisotropic strain fields in granular GaAs:MnAs epitaxial layers: Towards self-assembly of magnetic nanoparticles embedded in GaAscitations
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article
Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-β treatment.
Abstract
<h4>Background and purpose</h4>Ubiquitin specific peptidase 18 (USP18) is a deubiquitinating enzyme that functions as a negative regulator of the type I interferon (IFN) signalling pathway and is specifically induced by type I IFNs. In the present study, previous observations by our group were expanded suggesting an implication of USP18 in multiple sclerosis (MS) based on the finding of a deficient expression of the gene in peripheral blood mononuclear cells from MS patients compared with healthy controls.<h4>Methods</h4>Two polymorphisms, rs2542109 (intronic) and rs9618216 (promoter), were genotyped in a cohort of 691 relapse-onset MS patients and 1028 healthy controls and in 225 MS patients treated with IFNβ and classified into responders and non-responders after 2 years of treatment according to clinical criteria. Correlations between genotypes and expression levels for USP18 and its target ISG15 were performed by real-time polymerase chain reaction.<h4>Results</h4>Two USP18 haplotypes were significantly associated with MS, TG and CG. Additional experiments revealed that CG carriers were characterized by lower USP18 gene expression levels in peripheral blood mononuclear cells and higher clinical disease activity. Finally, AA homozygosis for the intronic polymorphism rs2542109 was associated with the responder phenotype; however, USP18 expression levels induced by IFNβ did not differ amongst MS patients carrying different rs2542109 genotypes.<h4>Conclusions</h4>Altogether, these results point to a role of USP18 in MS pathogenesis and the therapeutic response to IFNβ.