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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zhang, Yan
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2023Recyclable 3D‐Printed Aqueous Lithium‐Ion Batterycitations
- 2023Controlling Charge Transport in 2D Conductive MOFs─The Role of Nitrogen-Rich Ligands and Chemical Functionality.citations
- 2022Interface Stability between Na3Zr2Si2PO12 Solid Electrolyte and Sodium Metal Anode for Quasi-Solid-State Sodium Batterycitations
- 2022Ultrasonic Transducers made from Freeze-Cast Porous Piezoceramicscitations
- 2021Piezoelectric tunability and topological insulator transition in a GaN/InN/GaN quantum-well devicecitations
- 2021Patch test–relevant concentrations of metal salts cause localized cytotoxicity, including apoptosis, in skin ex vivocitations
- 2021Correlation between dielectric, mechanical properties and electromechanical performance of functionalized graphene / polyurethane nanocompositescitations
- 2020Self-healing dielectric elastomers for damage-Tolerant actuation and energy harvestingcitations
- 2020Harnessing Plasticity in an Amine-Borane as a Piezoelectric and Pyroelectric Flexible Filmcitations
- 2019Piezoelectric performance of PZT-based materials with aligned porosity::experiment and modellingcitations
- 2019Ice-templated poly(vinylidene fluoride) ferroelectretscitations
- 2019Piezoelectric performance of PZT-based materials with aligned porosity:citations
- 20181-3-Type Composites Based on Ferroelectrics:Electromechanical Coupling, Figures of Merit, and Piezotechnical Energy-Harvesting Applicationscitations
- 2018Understanding the effect of porosity on the polarisation-field response of ferroelectric materialscitations
- 20181-3-Type Composites Based on Ferroelectricscitations
- 2018Ice-templated poly(vinylidene fluoride) ferroelectretscitations
- 2016Tannic Acid and Cholesterol-Dopamine as Building Blocks in Composite Coatings for Substrate-Mediated Drug Deliverycitations
- 2016Tannic Acid and Cholesterol-Dopamine as Building Blocks in Composite Coatings for Substrate-Mediated Drug Deliverycitations
Places of action
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article
Patch test–relevant concentrations of metal salts cause localized cytotoxicity, including apoptosis, in skin ex vivo
Abstract
<p>Background: Metal alloys containing contact sensitizers (nickel, palladium, titanium) are extensively used in medical devices, in particular dentistry and orthopaedic surgery. The skin patch test is used to test for metal allergy. Objective: To determine whether metal salts, when applied to freshly excised skin at patch test–relevant concentrations and using a method which mimics skin patch testing, cause in changes in the epidermis and dermis. Methods: Tissue histology, apoptosis, metabolic activity, and inflammatory cytokine release were determined for two nickel salts, two palladium salts, and four titanium salts. Results: Patch test–relevant concentrations of all metal salts caused localized cytotoxicity. This was observed as epidermis separation at the basement membrane zone, formation of vacuoles, apoptotic nuclei, decreased metabolic activity, and (pro)inflammatory cytokine release. Nickel(II) sulfate hexahydrate, nickel(II) chloride hexahydrate, titanium(IV) bis(ammonium lactato)dihydroxide, and calcium titanate were highly cytotoxic. Palladium(II) chloride, sodium tetrachloropalladate(II), titanium(IV) isopropoxide, and titanium(IV) dioxide showed mild cytotoxicity. Conclusion: The patch test in itself may be damaging to the skin of the patient being tested. These results need further verification with biopsies obtained during clinical patch testing. The future challenge is to remain above the elicitation threshold at noncytotoxic metal concentrations.</p>