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| Azevedo, Nuno Monteiro |
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Foulds, Ian G.
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Publications (4/4 displayed)
- 2016Piezoelectric transducer array microspeakercitations
- 2015Electromagnetically powered electrolytic pump and thermo-responsive valve for drug deliverycitations
- 2015Towards a digital sound reconstruction MEMS device: Characterization of a single PZT based piezoelectric actuatorcitations
- 2014Crude oil water-cut sensing with disposable laser ablated and inkjet printed RF microfluidicscitations
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document
Electromagnetically powered electrolytic pump and thermo-responsive valve for drug delivery
Abstract
A novel drug delivery device is presented, implementing an electrolytic pump and a thermo-responsive valve. The device is remotely operated by an AC electromagnetic field (40.5∼58.5 mT, 450 kHz) that provides the power for the pump and the valve. It is suitable for long-term therapy applications, which use a solid drug in reservoir (SDR) approach and avoids unwanted drug diffusion. When the electromagnetic field is on, the electrolytic pump drives the drug towards the valve. The valve is made of a magnetic composite consisting of a smart hydrogel: Poly (N-Isopropylacrylamide) (PNIPAm) and iron powder. The heat generated in the iron powder via magnetic losses causes the PNIPAm to shrink, allowing the drug to flow past it. When the electromagnetic field is off, the PNIPAm swells, sealing the outlet. In the meantime, the bubbles generated by electrolysis recombine into water, causing a pressure reduction in the pumping chamber. This draws fresh fluid from outside the pump into the drug reservoir before the valve is fully sealed. The recombination can be accelerated by a platinum (Pt) coated catalytic reformer, allowing more fluid to flow back to the drug reservoir and dissolve the drug. By repeatedly turning on and off the magnetic field, the drug solution can be delivered cyclically. © 2015 IEEE.