| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Turza, Alexandru
National Institute for Research and Development of Isotopic and Molecular Technologies
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2023Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery Systemcitations
- 2022Structural studies of various olmesartan solvatescitations
- 2021New solvates and a salt of the anti-HIV compound etravirinecitations
- 2020Photocatalytic and Electrocatalytic Properties of NGr-ZnO Hybrid Materialscitations
- 2020Exploring the Polymorphism of Drostanolone Propionatecitations
- 2019Graphene/silver nanoparticles‐based surface‐enhanced Raman spectroscopy detection platforms: Application in the study of DNA molecules at low pHcitations
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article
Structural studies of various olmesartan solvates
Abstract
<jats:p>Seven solvates of the angiotensin II receptor blocker agent olmesartan (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>), namely, the methanol (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>·CH<jats:sub>4</jats:sub>O), ethanol (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>·C<jats:sub>2</jats:sub>H<jats:sub>6</jats:sub>O), isopropanol (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>·C<jats:sub>3</jats:sub>H<jats:sub>8</jats:sub>O), isobutanol (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>·C<jats:sub>4</jats:sub>H<jats:sub>10</jats:sub>O), 2-ethoxyethanol (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>·C<jats:sub>4</jats:sub>H<jats:sub>10</jats:sub>O<jats:sub>2</jats:sub>), chloroform (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>·CHCl<jats:sub>3</jats:sub>) and acetonitrile (C<jats:sub>24</jats:sub>H<jats:sub>26</jats:sub>N<jats:sub>6</jats:sub>O<jats:sub>3</jats:sub>·C<jats:sub>2</jats:sub>H<jats:sub>3</jats:sub>N) solvates, were successfully obtained. The crystal structures were determined using the single-crystal X-ray diffraction technique and the structural features are described, each solvate containing one molecule of olmesartan and one of solvent in the asymmetric unit. The samples were also analyzed by powder X-ray diffraction. Total lattice energies and binding energies between the olmesartan and solvent molecules were evaluated, which can be partitioned into electrostatic, polarization, dispersion and repulsion components. Hirshfeld and fingerprint plot analysis was performed to highlight the intermolecular contacts. Hydrogen bonding and supramolecular arrangements were comparatively studied for the seven solvates.</jats:p>