• Al-Harrasi, Ahmed
• Anwar, Muhammad
• Rawson, Jeremy M.
• Shah, Zarbad
• Shah, Syed Raza
• Khan, Ajmal
• Hussain, Javid
• Al-Harrasi, Rashid

Abstract

<jats:p>Reactions of 1,10-phenanthroline (phen) and 2-(3,4-dichlorophenyl)acetic acid (dcaH) with <jats:italic>M<jats:sub>n</jats:sub></jats:italic>(CO<jats:sub>3</jats:sub>) (<jats:italic>M</jats:italic> = Li<jats:sup>I</jats:sup>, Na<jats:sup>I</jats:sup> and Mg<jats:sup>II</jats:sup>; <jats:italic>n</jats:italic> = 1 and 2) in MeOH yield the mononuclear lithium complex aqua[2-(3,4-dichlorophenyl)acetato-κ<jats:italic>O</jats:italic>](1,10-phenanthroline-κ<jats:sup>2</jats:sup><jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>′)lithium(I), [Li(C<jats:sub>8</jats:sub>H<jats:sub>5</jats:sub>Cl<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>)(C<jats:sub>12</jats:sub>H<jats:sub>8</jats:sub>N<jats:sub>2</jats:sub>)(H<jats:sub>2</jats:sub>O)] or [Li(dca)(phen)(H<jats:sub>2</jats:sub>O)] (<jats:bold>1</jats:bold>), the dinuclear sodium complex di-μ-aqua-bis{[2-(3,4-dichlorophenyl)acetato-κ<jats:italic>O</jats:italic>](1,10-phenanthroline-κ<jats:sup>2</jats:sup><jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>′)sodium(I)}, [Na<jats:sub>2</jats:sub>(C<jats:sub>8</jats:sub>H<jats:sub>5</jats:sub>Cl<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>)<jats:sub>2</jats:sub>(C<jats:sub>12</jats:sub>H<jats:sub>8</jats:sub>N<jats:sub>2</jats:sub>)<jats:sub>2</jats:sub>(H<jats:sub>2</jats:sub>O)<jats:sub>2</jats:sub>] or [Na<jats:sub>2</jats:sub>(dca)<jats:sub>2</jats:sub>(phen)<jats:sub>2</jats:sub>(H<jats:sub>2</jats:sub>O)<jats:sub>2</jats:sub>] (<jats:bold>2</jats:bold>), and the one-dimensional chain magnesium complex <jats:italic>catena</jats:italic>-poly[[[diaqua(1,10-phenanthroline-κ<jats:sup>2</jats:sup><jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>′)magnesium]-μ-2-(3,4-dichlorophenyl)acetato-κ<jats:sup>2</jats:sup><jats:italic>O</jats:italic>:<jats:italic>O</jats:italic>′] 2-(3,4-dichlorophenyl)acetate monohydrate], {[Mg(C<jats:sub>8</jats:sub>H<jats:sub>5</jats:sub>Cl<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>)(C<jats:sub>12</jats:sub>H<jats:sub>8</jats:sub>N<jats:sub>2</jats:sub>)(H<jats:sub>2</jats:sub>O)<jats:sub>2</jats:sub>](C<jats:sub>8</jats:sub>H<jats:sub>5</jats:sub>Cl<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>)·H<jats:sub>2</jats:sub>O}<jats:sub><jats:italic>n</jats:italic></jats:sub> or {[Mg(dca)(phen)(H<jats:sub>2</jats:sub>O)<jats:sub>2</jats:sub>](dca)·H<jats:sub>2</jats:sub>O}<jats:sub><jats:italic>n</jats:italic></jats:sub> (<jats:bold>3</jats:bold>). In these complexes, phen binds <jats:italic>via</jats:italic> an <jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>′-chelate pocket, while the deprotonated dca<jats:sup>−</jats:sup> ligands coordinate either in a monodentate (in <jats:bold>1</jats:bold> and <jats:bold>2</jats:bold>) or bidentate (in <jats:bold>3</jats:bold>) fashion. The remaining coordination sites around the metal ions are occupied by water molecules in all three complexes. Complex <jats:bold>1</jats:bold> crystallizes in the triclinic space group <jats:italic>P</jats:italic>{1} with one molecule in the asymmetric unit. The Li<jats:sup>+</jats:sup> ion adopts a four-coordinated distorted seesaw geometry comprising an [N<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>] donor set. Complex <jats:bold>2</jats:bold> crystallizes in the triclinic space group <jats:italic>P</jats:italic>{1} with half a molecule in the asymmetric unit, in which the Na<jats:sup>+</jats:sup> ion adopts a five-coordinated distorted spherical square-pyramidal geometry, with an [N<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub>] donor set. Complex <jats:bold>3</jats:bold> crystallizes in the orthorhombic space group <jats:italic>P</jats:italic>2<jats:sub>1</jats:sub>2<jats:sub>1</jats:sub>2<jats:sub>1</jats:sub>, with one Mg<jats:sup>2+</jats:sup> ion, one phen ligand, two dca<jats:sup>−</jats:sup> ligands and three water molecules in the asymmetric unit. Both dcaH ligands are deprotonated, however, one dca<jats:sup>−</jats:sup> anion is not coordinated, whereas the second dca<jats:sup>−</jats:sup> anion coordinates in a bidentate fashion bridging two Mg<jats:sup>2+</jats:sup> ions, resulting in a one-dimensional chain structure for <jats:bold>3</jats:bold>. The Mg<jats:sup>2+</jats:sup> ion adopts a distorted octahedral geometry, with an [N<jats:sub>2</jats:sub>O<jats:sub>4</jats:sub>] donor set. Complexes <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold> were evaluated against urease and α-glucosidase enzymes for their inhibition potential and were found to be inactive.</jats:p>

Topics

• impedance spectroscopy
• Magnesium
• Magnesium
• Sodium
• Lithium
• one-dimensional
• space group
• bioactivity