| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Frielinghaus, Henrich
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2023Nanostructured block copolymer single-ion conductors for low-temperature, high-voltage and fast charging lithium-metal batteriescitations
- 2022Controlled LCST Behavior and Structure Formation of Alternating Amphiphilic Copolymers in Watercitations
- 2021Flexible Sample Environment for the Investigation of Soft Matter at the European Spallation Source: Part II—The GISANS Setupcitations
- 2021Inelastic neutron scattering analysis with time-dependent Gaussian-field modelscitations
- 2021Applied Sciences / Flexible Sample Environment for the Investigation of Soft Matter at the European Spallation Source: Part II—The GISANS Setupcitations
- 2021Distribution and orientation of nerve fibers and myelin assembly in a brain section retrieved by small-angle neutron scatteringcitations
- 2021Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part III—The Macroscopic Foam Cellcitations
- 2021Technical Specification of the Small-Angle Neutron Scattering Instrument SKADI at the European Spallation Sourcecitations
- 2021Mutually Beneficial Combination of Molecular Dynamics Computer Simulations and Scattering Experimentscitations
- 2021Tunable Hydrogels with Improved Viscoelastic Properties from Hybrid Polypeptidescitations
- 20203D printed spherical environmental chamber for neutron reflectometry and grazing-incidence small-angle neutron scattering experimentscitations
- 2020In operando monitoring of wood transformation during pretreatment with ionic liquidscitations
- 2020Morphology of Thin Film Composite Membranes Explored by Small-Angle Neutron Scattering and Positron-Annihilation Lifetime Spectroscopycitations
- 2019In Situ Monitoring Mesoscopic Deformation of Nanostructured Porous Titania Films Caused by Water Ingressioncitations
- 2019Water-Induced Structural Rearrangements on the Nanoscale in Ultrathin Nanocellulose Filmscitations
- 2018Deformation of Mesoporous Titania Nanostructures in Contact with D$_{2}$O Vaporcitations
- 2018Preferential Orientation of Crystals Induced by Incorporation of Organic Ligands in Mixed-Dimensional Hybrid Perovskite Filmscitations
- 2018Deformation of Mesoporous Titania Nanostructures in Contact with D2O Vaporcitations
- 2018Preferential Orientation of Crystals Induced by Incorporation of Organic Ligands in Mixed‐Dimensional Hybrid Perovskite Filmscitations
- 2017Influence of the amphiphilicity profile of copolymers on the formation of liquid crystalline mesophases in microemulsionscitations
- 2016The effect of amphiphilic polymers with a continuous philicity profile on the membrane properties in a bicontinuous microemulsions studied by neutron scattering
- 2016Amphiphilic Polymers with a Continuous Philicity Profile in Bicontinuous Microemulsions Studied by Quasielastic Neutron Scattering
- 2014Stealth carriers for low-resolution structure determination of membrane proteins in solutioncitations
- 2013Magnetization reversal in Nd-Fe-B based nanocomposites as seen by magnetic small-angle neutron scatteringcitations
- 2013Studying Model samples to understand mechanical Properties of filled Elastomers
Places of action
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article
Stealth carriers for low-resolution structure determination of membrane proteins in solution
Abstract
<p>Structural studies of membrane proteins remain a great experimental challenge. Functional reconstitution into artificial nanoscale bilayer disc carriers that mimic the native bilayer environment allows the handling of membrane proteins in solution. This enables the use of small-angle scattering techniques for fast and reliable structural analysis. The difficulty with this approach is that the carrier discs contribute to the measured scattering intensity in a highly nontrivial fashion, making subsequent data analysis challenging. Here, an elegant solution to circumvent the intrinsic complexity brought about by the presence of the carrier disc is presented. In combination with small-angle neutron scattering (SANS) and the D2O/H2O-based solvent contrast-variation method, it is demonstrated that it is possible to prepare specifically deuterated carriers that become invisible to neutrons in 100% D2O at the length scales relevant to SANS. These 'stealth' carrier discs may be used as a general platform for low-resolution structural studies of membrane proteins using well established data-analysis tools originally developed for soluble proteins.</p>