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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Houben, Lothar
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024A Gd-doped ceria/TiOx nanocomposite as the active layer in a three terminal electrochemical resistivity switch.citations
- 2024W18O49 Nanowhiskers Decorating SiO2 Nanofibers: Lessons from In Situ SEM/TEM Growth to Large Scale Synthesis and Fundamental Structural Understandingcitations
- 2023W18O49 Nanowhiskers Decorating SiO2 Nanofiberscitations
- 2023Encapsulation of Uranium Oxide in Multiwall WS<sub>2</sub> Nanotubes
- 2022Polar Crystal Habit and 3D Electron Diffraction Reveal the Malaria Pigment Hemozoin as a Selective Mixture of Centrosymmetric and Chiral Stereoisomerscitations
- 2022Nanotubes from the Misfit Layered Compound (SmS)1.19TaS2citations
- 2022Nanotubes from the Misfit Layered Compound $(SmS)_{1.19}TaS_2$ : Atomic Structure, Charge Transfer, and Electrical Propertiescitations
- 2020Large lattice distortions and size-dependent bandgap modulation in epitaxial halide perovskite nanowirescitations
- 2020Large lattice distortions and size-dependent bandgap modulation in epitaxial halide perovskite nanowirescitations
- 2018Guided Growth of Horizontal ZnS Nanowires on Flat and Faceted Sapphire Surfacescitations
- 2018A Mechanistic Study of Phase Transformation in Perovskite Nanocrystals Driven by Ligand Passivationcitations
- 2016Tubular structures from the LnS–TaS₂ (Ln = La, Ce, Nd, Ho, Er) and LaSe–TaSe₂ misfit layered compoundscitations
- 2016From dilute isovalent substitution to alloying in CdSeTe nanoplateletscitations
- 2008Metadislocations in the orthorhombic structurally complex alloy Al13Co4citations
- 2006Atomic-resolution imaging of lattice imperfections in semiconductors by conjoined aberration-corrected HRTEM and exit-plane wavefunction retrievalcitations
- 2000Plasmaabscheidung von mikrokristallinem Silizium: Merkmale und Mikrostruktur und deren Deutung im Sinne von Wachstumsvorgängen
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document
Polar Crystal Habit and 3D Electron Diffraction Reveal the Malaria Pigment Hemozoin as a Selective Mixture of Centrosymmetric and Chiral Stereoisomers
Abstract
<jats:title>Abstract</jats:title><jats:p>Detoxification of heme in Plasmodium depends on its crystallization into hemozoin. This pathway is a major target of antimalarial drugs. X-ray powder diffraction has established that the unit cell contains a cyclic hematin dimer, yet the pro-chiral nature of heme supports formation of four distinct stereoisomers, two centrosymmetric and two chiral enantiomers. Here we apply emerging methods of in situ cryo-electron tomography and diffraction to obtain a definitive structure of biogenic hemozoin. Individual crystals take a striking polar morphology. Diffraction analysis, supported by density functional theory, indicates a compositional mixture of one centrosymmetric and one chiral dimer, whose absolute configuration has been determined on the basis of crystal morphology and interaction with the aqueous medium. Structural modeling of the heme detoxification protein suggests a mechanism for dimer selection. The refined structure of hemozoin should serve as a guide to new drug development.</jats:p>