| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Tovar, Nick
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 20233D Printing Type 1 Bovine Collagen Scaffolds for Tissue Engineering Applications—Physicochemical Characterization and In Vitro Evaluationcitations
- 2023Engineering 3D Printed Bioceramic Scaffolds to Reconstruct Critical-Sized Calvaria Defects in a Skeletally Immature Pig Modelcitations
- 2022Residual stress estimated by nanoindentation in pontics and abutments of veneered zirconia fixed dental prosthesescitations
- 2022Physiochemical and bactericidal activity evaluationcitations
- 2021Three-Dimensionally-Printed Bioactive Ceramic Scaffoldscitations
- 2021Effect of supplemental acid-etching on the early stages of osseointegrationcitations
- 2020Assessing osseointegration of metallic implants with boronized surface treatmentcitations
- 2019Synergistic effects of implant macrogeometry and surface physicochemical modifications on osseointegrationcitations
- 2019Repair of Critical-Sized Long Bone Defects Using Dipyridamole-Augmented 3D-Printed Bioactive Ceramic Scaffoldscitations
- 2018Form and functional repair of long bone using 3D-printed bioactive scaffoldscitations
- 2014The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materialscitations
- 2014The in vivo effect of P-15 coating on early osseointegrationcitations
- 2014Nanometer-scale features on micrometer-scale surface texturingcitations
- 2012Physicochemical characterization and in vivo evaluation of amorphous and partially crystalline calcium phosphate coatings fabricated on Ti-6Al-4V implants by the plasma spray methodcitations
Places of action
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article
Engineering 3D Printed Bioceramic Scaffolds to Reconstruct Critical-Sized Calvaria Defects in a Skeletally Immature Pig Model
Abstract
<jats:sec><jats:title>Background:</jats:title><jats:p>Three-dimensional printed bioceramic scaffolds composed of 100% β-tricalcium phosphate augmented with dipyridamole (3DPBC-DIPY) can regenerate bone across critically sized defects in skeletally mature and immature animal models. Before human application, safe and effective bone formation should be demonstrated in a large translational animal model. This study evaluated the ability of 3DPBC-DIPY scaffolds to restore critically sized calvarial defects in a skeletally immature, growing minipig.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Unilateral calvarial defects (~1.4 cm) were created in 6-week-old Göttingen minipigs (<jats:italic toggle="yes">n</jats:italic> = 12). Four defects were filled with a 1000 μm 3DPBC-DIPY scaffold with a cap (a solid barrier on the ectocortical side of the scaffold to prevent soft-tissue infiltration), four defects were filled with a 1000 μm 3DPBC-DIPY scaffold without a cap, and four defects served as negative controls (no scaffold). Animals were euthanized 12 weeks postoperatively. Calvariae were subjected to micro–computed tomography, 3D reconstruction with volumetric analysis, qualitative histologic analysis, and nanoindentation.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Scaffold-induced bone growth was statistically greater than in negative controls (<jats:italic toggle="yes">P</jats:italic> ≤ 0.001), and the scaffolds with caps produced significantly more bone generation compared with the scaffolds without caps (<jats:italic toggle="yes">P</jats:italic> ≤ 0.001). Histologic analysis revealed woven and lamellar bone with haversian canals throughout the regenerated bone. Cranial sutures were observed to be patent, and there was no evidence of ectopic bone formation or excess inflammatory response. Reduced elastic modulus and hardness of scaffold-regenerated bone were found to be statistically equivalent to native bone (<jats:italic toggle="yes">P</jats:italic> = 0.148 for reduced elastic modulus of scaffolds with and without caps and <jats:italic toggle="yes">P</jats:italic> = 0.228 and <jats:italic toggle="yes">P</jats:italic> = 0.902 for hardness of scaffolds with and without caps, respectively).</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>3DPBC-DIPY scaffolds have the capacity to regenerate bone across critically sized calvarial defects in a skeletally immature translational pig model.</jats:p></jats:sec><jats:sec><jats:title>Clinical Relevance Statement:</jats:title><jats:p>This study assessed the bone generative capacity of 3D-printed bioceramic scaffolds composed of 100% β-tricalcium phosphate and augmented with dipyridamole placed within critical-sized calvarial defects in a growing porcine model.</jats:p></jats:sec>