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Werner, Guido
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article
Characterization of Methicillin-resistant Staphylococcus aureus From Children at Hospital Admission: Experiences From a Hospital in a German Metropolitan Area
Abstract
<jats:sec><jats:title>Background:</jats:title><jats:p>Since the 1990s, community-associated Methicillin-resistant <jats:italic toggle="yes">Staphylococcus aureus</jats:italic> (CA-MRSA) are described as emerging independent of health care. CA-MRSA is associated with the colonization and infection of healthy, immunocompetent younger individuals. While skin and soft tissue infections (SSTI) are predominant, life-threatening syndromes can also occur.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>In this retrospective study, we investigated MRSA stains isolated from community-onset infections and from MRSA screening of children at admission to a tertiary-care hospital in 2012–2018. In total, 102 isolates were subjected to antibiotic susceptibility testing by broth microdilution, <jats:italic toggle="yes">spa</jats:italic>-typing, multilocus sequence typing, SCC<jats:italic toggle="yes">mec</jats:italic>typing and virulence/resistance gene detection by polymerase chain reaction.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>The majority of isolates originated from community-onset infections (80/102), of these primarily from SSTI (70/80). Additional strains were isolated by MRSA screening (22/102). In total 61.8% of the MRSA carried the gene for the Panton-Valentine leukocidin (<jats:italic toggle="yes">lukPV</jats:italic>). Molecular characterization of isolates revealed various epidemic MRSA clones, circulating in both community and hospital settings. Most prevalent epidemic lineages were isolates of the “European CA-MRSA clone” (CC80-MRSA-IV), the “Bengal Bay clone” (ST772-MRSA-V), or the “USA300 NAE clone” (ST8-MRSA-IVa).</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Our data highlight the importance of CA-MRSA causing SSTI in children. More frequent microbiological and molecular analysis of these strains is important for targeted treatment and can provide valuable data for molecular surveillance of the pathogen.</jats:p></jats:sec>