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Gupta, Govind
in Cooperation with on an Cooperation-Score of 37%
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Publications (5/5 displayed)
- 2023Atomically Thin Gallium Nitride for High‐Performance Photodetectioncitations
- 2020Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cellscitations
- 2020Phase dependent radiation hardness and performance analysis of amorphous and polycrystalline Ga2O3 solar-blind photodetector against swift heavy ion irradiationcitations
- 2017High transmittance contrast in amorphous to hexagonal phase of Ge2Sb2Te5: Reversible NIR-windowcitations
- 2017Wet chemical etching induced stress relaxed nanostructures on polar & non-polar epitaxial GaN filmscitations
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article
Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cells
Abstract
he neurotoxicity of hard metal-based nanoparticles (NPs) remains poorly understood. Here, we deployed the human neuroblastoma cell line SH-SY5Y differentiated or not into dopaminergic- and cholinergic-like neurons to study the impact of tungsten carbide (WC) NPs, WC NPs sintered with cobalt (Co), or Co NPs versus soluble CoCl2. Co NPs and Co salt triggered a dose-dependent cytotoxicity with an increase in cytosolic calcium, lipid peroxidation, and depletion of glutathione (GSH). Co NPs and Co salt also suppressed glutathione peroxidase 4 (GPX4) mRNA and protein expression. Co-exposed cells were rescued by N-acetylcysteine (NAC), a precursor of GSH, and partially by liproxstatin-1, an inhibitor of lipid peroxidation. Furthermore, in silico analyses predicted a significant correlation, based on similarities in gene expression profiles, between Co-containing NPs and Parkinson's disease, and changes in the expression of selected genes were validated by RT-PCR. Finally, experiments using primary human dopaminergic neurons demonstrated cytotoxicity and GSH depletion in response to Co NPs and CoCl2 with loss of axonal integrity. Overall, these data point to a marked neurotoxic potential of Co-based but not WC NPs and show that neuronal cell death may occur through a ferroptosis-like mechanism.