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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kumar, Sunil
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2024SMART-SLE: serology monitoring and repeat testing in systemic lupus erythematosus—an analysis of anti-double-stranded DNA monitoringcitations
- 2023Carbon-fibre-reinforced-PEEK and silicon doped amorphous carbon as a potential tribopair for implant applicationcitations
- 2023Comparative evaluation of dithranol-loaded nanosponges fabricated by solvent evaporation technique and melt methodcitations
- 2023Electrohydrodynamic capillary instability of Rivlin–Ericksen viscoelastic fluid film with mass and heat transfercitations
- 2022Formulation, Characterization, Anti-Inflammatory and Cytotoxicity Study of Sesamol-Laden Nanospongescitations
- 2021Recop: Fine-grained Opinions and Collaborative Filtering based Recommender System for Industry 5.0citations
- 2021Single-shot phase contrast microscopy using polarisation-resolved differential phase contrast
- 2020Increase in energy efficiency of a steel billet reheating furnace by heat balance study and process improvementcitations
- 2017Visible thermochromism in vanadium pentoxide coatingscitations
- 2016Effect of uniformly applied force and molecular characteristics of a polymer chain on its adhesion to graphene substratescitations
- 2016Electrical Switching in Semiconductor-Metal Self-Assembled VO2 Disordered Metamaterial Coatingscitations
- 2011Influence of hydrogen content on impact toughness of Zr-2.5Nb pressure tube alloycitations
- 2010Terahertz Spectroscopy of Single-Walled Carbon Nanotubes in a Polymer Film: Observation of Low-Frequency Phononscitations
- 2010Friction, wear and surface characterization of metal-on-metal implant in protein rich lubrications
Places of action
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article
SMART-SLE: serology monitoring and repeat testing in systemic lupus erythematosus—an analysis of anti-double-stranded DNA monitoring
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Disease activity monitoring in SLE includes serial measurement of anti-double stranded-DNA (dsDNA) antibodies, but in patients who are persistently anti-dsDNA positive, the utility of repeated measurement is unclear. We investigated the usefulness of serial anti-dsDNA testing in predicting flare in SLE patients who are persistently anti-dsDNA positive.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Data were analysed from patients in a multinational longitudinal cohort with known anti-dsDNA results from 2013 to 2021. Patients were categorized based on their anti-dsDNA results as persistently negative, fluctuating or persistently positive. Cox regression models were used to examine longitudinal associations of anti-dsDNA results with flare.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Data from 37 582 visits of 3484 patients were analysed. Of the patients 1029 (29.5%) had persistently positive anti-dsDNA and 1195 (34.3%) had fluctuating results. Anti-dsDNA expressed as a ratio to the normal cut-off was associated with the risk of subsequent flare, including in the persistently positive cohort (adjusted hazard ratio [HR] 1.56; 95% CI: 1.30, 1.87; P &lt; 0.001) and fluctuating cohort (adjusted HR 1.46; 95% CI: 1.28, 1.66), both for a ratio &gt;3. Both increases and decreases in anti-dsDNA more than 2-fold compared with the previous visit were associated with increased risk of flare in the fluctuating cohort (adjusted HR 1.33; 95% CI: 1.08, 1.65; P = 0.008) and the persistently positive cohort (adjusted HR 1.36; 95% CI: 1.08, 1.71; P = 0.009).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Absolute value and change in anti-dsDNA titres predict flares, including in persistently anti-dsDNA positive patients. This indicates that repeat monitoring of dsDNA has value in routine testing.</jats:p></jats:sec>