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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Dolatshahi-Pirouz, Alireza
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2024Engineering Photo-Cross-Linkable MXene-Based Hydrogels:Durable Conductive Biomaterials for Electroactive Tissues and Interfacescitations
- 2024Engineering Photo-Cross-Linkable MXene-Based Hydrogels: Durable Conductive Biomaterials for Electroactive Tissues and Interfacescitations
- 2023Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healingcitations
- 2023Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interfacecitations
- 2022Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repaircitations
- 2021Design and construction of a novel measurement device for mechanical characterization of hydrogelscitations
- 2021Design and construction of a novel measurement device for mechanical characterization of hydrogels:A case studycitations
- 2021Combinatorial fluorapatite-based scaffolds substituted with strontium, magnesium and silicon ions for mending bone defectscitations
- 2021Rheological characterization of 3D printable geopolymerscitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 20193D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineeringcitations
- 2019Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?citations
- 2019Silica nanoparticle surface chemistry: An important trait affecting cellular biocompatibility in two and three dimensional culture systemscitations
- 2019Combating Microbial Contamination with Robust Polymeric Nanofibers: Elemental Effect on the Mussel-Inspired Cross-Linking of Electrospun Gelatincitations
- 2017Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissuescitations
- 2017Nanoreinforced hydrogels for tissue engineering:Biomaterials that are compatible with load-bearing and electroactive tissuescitations
- 2016Injectable shear-thinning nanoengineered hydrogels for stem cell deliverycitations
- 2011Growth characteristics of inclined columns produced by Glancing Angle Deposition (GLAD) and colloidal lithographycitations
- 2010Synthesis of functional nanomaterials via colloidal mask templating and glancing angle deposition (GLAD)”
Places of action
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article
3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering
Abstract
Additive manufacturing (AM) has shown promise in designing 3D scaffold for regenerative medicine. However, many synthetic biomaterials used for AM are bioinert. Here, we report synthesis of bioactive nanocomposites from a poly(ethylene oxide terephthalate) (PEOT)/poly(butylene terephthalate) (PBT) (PEOT/PBT) copolymer and 2D nanosilicates for fabricating 3D scaffolds for bone tissue engineering. PEOT/PBT have been shown to support calcification and bone bonding ability in vivo, while 2D nanosilicates induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in absence of osteoinductive agents. The effect of nanosilicates addition to PEOT/PBT on structural, mechanical and biological properties is investigated. Specifically, the addition of nanosilicate to PEOT/PBT improves the stability of nanocomposites in physiological conditions, as nanosilicate suppressed the degradation rate of copolymer. However, no significant increase in the mechanical stiffness of scaffold due to the addition of nanosilicates is observed. The addition of nanosilicates to PEOT/PBT improves the bioactive properties of AM nanocomposites as demonstrated in vitro. hMSCs readily proliferated on the scaffolds containing nanosilicates and resulted in significant upregulation of osteo-related proteins and production of mineralized matrix. The synergistic ability of nanosilicates and PEOT/PBT can be utilized for designing bioactive scaffolds for bone tissue engineering.