| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Allain, Magali
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024Chiral Truxene‐Based Self‐Assembled Cages: Triple Interlocking and Supramolecular Chirogenesiscitations
- 2024Chiral Truxene‐Based Self‐Assembled Cages: Triple Interlocking and Supramolecular Chirogenesis
- 2024Perovskite versus Nonperovskite: Modulating the Nature and Optical Properties of One-Dimensional Chiral Lead–Bromide Networkscitations
- 2023Halide Containing Short Organic Monocations in n = 1–4 2D Multilayered Halide Perovskite Thin Films and Crystalscitations
- 2023A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progressioncitations
- 2023Azido‐Functionalized Fullerenes, Perylenediimide, Perylene, and Tetraphenylethylene as Crosslinkers for Applications in Materials Sciencecitations
- 2022Synthesis and Characterization of (FA)3(HEA)2Pb3I11: A Rare Example of <1 1 0>-Oriented Multilayered Halide Perovskitescitations
- 2022Synthesis and Characterization of (FA) 3 (HEA) 2 Pb 3 I 11 : A Rare Example of <1 1 0>-Oriented Multilayered Halide Perovskitescitations
- 2021From Zero- to One-Dimensional, Opportunities and Caveats of Hybrid Iodobismuthates for Optoelectronic Applicationscitations
- 2021Old Donors for New Molecular Conductors: Combining TMTSF and BEDT-TTF with Anionic (TaF6)1−x/(PF6)x Alloyscitations
- 2020Synthesis, characterization and use of benzothioxanthene imide based dimerscitations
- 2020Synthesis, characterization and use of benzothioxanthene imide based dimerscitations
- 2020Combining Chirality and Hydrogen Bonding in Methylated Ethylenedithio-Tetrathiafulvalene Primary Diamide Precursors and Radical Cation Saltscitations
- 2020Conservation of structural arrangements and 3 : 1 stoichiometry in a series of crystalline conductors of TMTTF, TMTSF, BEDT-TTF, and chiral DM-EDT-TTF with the oxo-bis[pentafluorotantalate( v )] dianioncitations
- 2020Conservation of structural arrangements and 3 : 1 stoichiometry in a series of crystalline conductors of TMTTF, TMTSF, BEDT-TTF, and chiral DM-EDTTTF with the oxo-bis[pentafluorotantalate(V)] dianion
- 2015A Mechanofluorochromic Push-Pull Small Molecule with Aggregation-Controlled Linear and Nonlinear Optical Propertiescitations
- 2012Cyanomethylene-bis(phosphonate) as ditopical ligand: stepwise formation of a 2-D heterometallic Fe(III)-Ag(I) coordination networkcitations
- 2009Spectrometric Analyses, Structure and Voltammetric Study of Nickel(II) with N[(1E) Phenylmethylene N2[2(2Hydroxyphenylmethylene]Amino ethyl) Imidazolidin-1-yl Ethylaminecitations
Places of action
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article
A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression
Abstract
<jats:title>Abstract</jats:title><jats:p>Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report a new heavy-atom-free fluorescent G-quadruplex (G4) DNA-binding PS, named DBI. We reveal by fluorescence microscopy that DBI preferentially localizes in intraluminal vesicles (ILVs), precursors of exosomes, which are key components of cancer cell proliferation. Moreover, purified exosomal DNA was recognized by a G4-specific antibody, thus highlighting the presence of such G4-forming sequences in the vesicles. Despite the absence of fluorescence signal from DBI in nuclei, light-irradiated DBI-treated cells generated reactive oxygen species (ROS), triggering a 3-fold increase of nuclear G4 foci, slowing fork progression and elevated levels of both DNA base damage, 8-oxoguanine, and double-stranded DNA breaks. Consequently, DBI was found to exert significant phototoxic effects (at nanomolar scale) toward cancer cell lines and tumor organoids. Furthermore, in vivo testing reveals that photoactivation of DBI induces not only G4 formation and DNA damage but also apoptosis in zebrafish, specifically in the area where DBI had accumulated. Collectively, this approach shows significant promise for image-guided PDT.</jats:p>