| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Carvalho, R.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (26/26 displayed)
- 2023Improving the Performance of Paper-Based Dipole Antennas by Electromagnetic Flux Concentrationcitations
- 2017Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytescitations
- 2017The influence of cork on the thermal insulation properties of home textilescitations
- 2016Development of high-performance knitted structures for cut and puncture protection
- 2016A Study on the Durability Properties of Textile Membranes for Architectural Purposescitations
- 2016Estrutura fibrosa auxética com fios de elevado desempenho para proteção mecânica
- 2016Tecidos estreitos com capacidade de emissão de luz
- 2015Sistemas fibrosos de proteção contra o corte de motoserras
- 2015Re-Design of ribbon for new applications
- 2015Durability of natural fibers for geotechnical engineeringcitations
- 2015Natural fibers for soil reinforcement
- 2015Study on the degradation of natural fiber geotextiles
- 2015Development of High-performance Single Layer Weft Knitted Structures for Cut and Puncture Protection
- 2015Study of fibrous materials to reduce thermal signature
- 2014Vestuário de proteção para usuários de motosserra
- 2014Durabilidade de fibras naturais para geotecnia
- 2012Elastic behaviour of knitted fabrics for compression arm sleeves
- 2012Influence of structural and process parameters on mechanical behaviour of elastane yarns
- 2012Noise reduction performance of thermobonded nonwovens
- 2012Mechanical behaviour of knitted compression arm sleeves
- 2012Nonwovens in geotechnical applications
- 2011Mechanical properties of needle-punched nonwovens for geotechnical applications
- 2011Mechanical properties of needle-punched nonwovens for Geotechnical applications
- 2011Análise da influência da matéria-prima e dos parâmetros de produção nas propriedades mecânicas de não-tecidos agulhados para geotêxteis
- 2006Study on Geomembranes by Hot Compaction Process
- 2002Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinomacitations
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article
Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma
Abstract
Background: Both Helicobacter pylori genotype and host genetic polymorphisms play a role in determining the clinical consequences of H. pylori infection. We investigated whether there are any combinations of bacterial and host genotypes that are particularly associated with the occurrence of gastric carcinoma. Methods: Genotypic variations in virulence-associated genes of H. pylori vacA (s and m regions) and cagA were determined in 221 subjects with chronic gastritis and 222 patients with gastric carcinoma by polymerase chain reaction (PCR)-line probe assay. Polymorphisms in the human interleukin I beta (IL-1B) gene (IL-1B-511*C or IL-1B-511*T) and in the IL-1 receptor antagonist gene (IL-1RN intron 2 variable number of tandem repeats) were evaluated by PCR and single-strand conformation polymorphism analysis. All statistical tests were two-sided. Results: Infection with vacAs1-, vacAm1-, and cagA-positive strains of H. pylori was associated with an increased risk for gastric carcinoma, with odds ratios (ORs) of 17 (95% confidence interval [CI] = 7.8 to 38), 6.7 (95% CI = 3.6 to 12), and 15 (95% CI = 7.4 to 29), respectively. IL-1B-511*T carriers (IL-1B-511*T/*T or IL-1B-511*T/*C) homozygous for the short allele of IL-1RN (IL-1RN*2/*2) had an increased gastric carcinoma risk (OR = 3.3, 95% CI = 1.3 to 8.2). For each combination of bacterial/host genotype, the odds of having gastric carcinoma were greatest in those with both bacterial and host high-risk genotypes: vacAs1/IL-1B-511*T carrier (OR = 87, 95% CI = 11 to 679), vacAm1/IL-1B-511*T carrier (OR = 7.4, 95% CI = 3.2 to 17), cagA-positive/IL-1B511*T carrier (OR = 25, 95% CI = 8.2 to 77), vacAs1/IL1-RN*2/*2 (OR = 32, 95% CI = 7.8 to 134), vacAm1/IL-RN*2/*2 (OR = 8.8, 95% CI = 2.2 to 35), and cagA-positive/IL-1RN*2/*2 (OR = 23, 95% CI = 7.0 to 72). Conclusion Combined bacterial/host genotyping may provide an important tool in defining disease risk and targeting H. pylori eradication to high-risk individuals.