Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (1/1 displayed)

  • 2023Pediatric RSV Diagnostic Testing Performance: A Systematic Review and Meta-analysis24citations

Places of action

Chart of shared publication
Begier, Elizabeth
1 / 2 shared
Rozenbaum, Mark
1 / 1 shared
Rubbrecht, Michelle
1 / 1 shared
Aponte-Torres, Zuleika
1 / 1 shared
Atwell, Jessica
1 / 1 shared
Agarwal, Neha
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Moreo, Laura Mora
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Siapka, Mariana
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Kalina, Warren V.
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Machado, Belen
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Gessner, Bradford
1 / 1 shared
Onwuchekwa, Chukwuemeka
1 / 2 shared
Chart of publication period
2023

Co-Authors (by relevance)

  • Begier, Elizabeth
  • Rozenbaum, Mark
  • Rubbrecht, Michelle
  • Aponte-Torres, Zuleika
  • Atwell, Jessica
  • Agarwal, Neha
  • Moreo, Laura Mora
  • Siapka, Mariana
  • Vroling, Hilde
  • Nair, Harish
  • Menon, Sonia
  • Kalina, Warren V.
  • Machado, Belen
  • Gessner, Bradford
  • Onwuchekwa, Chukwuemeka
OrganizationsLocationPeople

article

Pediatric RSV Diagnostic Testing Performance: A Systematic Review and Meta-analysis

  • Begier, Elizabeth
  • Rozenbaum, Mark
  • Rubbrecht, Michelle
  • Aponte-Torres, Zuleika
  • Atwell, Jessica
  • Agarwal, Neha
  • Moreo, Laura Mora
  • Siapka, Mariana
  • Curcio, Daniel
  • Vroling, Hilde
  • Nair, Harish
  • Menon, Sonia
  • Kalina, Warren V.
  • Machado, Belen
  • Gessner, Bradford
  • Onwuchekwa, Chukwuemeka
Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Adding additional specimen types (e.g., serology or sputum) to nasopharyngeal swab (NPS) RT-PCR increases respiratory syncytial virus (RSV) detection among adults. We assessed if a similar increase occurs in children and quantified under-ascertainment associated with diagnostic testing.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We searched databases for studies involving RSV detection in persons &amp;lt;18 years using ≥2 specimen types or tests. We assessed study quality using a validated checklist. We pooled detection rates by specimen and diagnostic tests and quantified performance.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We included 157 studies. Added testing of additional specimens to NP aspirate (NPA), NPS and/or nasal swab (NS) RT-PCR resulted in statistically non-significant increases in RSV detection. Adding paired serology testing increased RSV detection by 10%, NS by 8%, oropharyngeal swabs by 5%, and NPS by 1%. Compared to RT-PCR, direct fluorescence antibody tests, viral culture, and rapid antigen tests were 87%, 76%, and 74% sensitive, respectively (pooled specificities all ≥98%). Pooled sensitivity of multiplex versus singleplex RT-PCR was 96%.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>RT-PCR was the most sensitive pediatric RSV diagnostic test. Adding multiple specimens did not substantially increase RSV detection, but even small proportional increases could result in meaningful changes in burden estimates. The synergistic effect of adding multiple specimens should be evaluated.</jats:p></jats:sec>

Topics
  • size-exclusion chromatography