| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Chen, Jie
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2024The Effect of Y Addition on Oxidation Resistance of Bulk W-Cr Alloys
- 2024Cooling rate uncovers epimer-dependent supramolecular organization of carbohydrate amphiphilescitations
- 2024Risk Factors for Intracerebral Hemorrhage: Genome-Wide Association Study and Mendelian Randomization Analysescitations
- 2023Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analysescitations
- 2023Molecular Engineering of Metalloporphyrins for High‐Performance Energy Storage: Central Metal Matterscitations
- 2021Antiferromagnetic Order Breaks Inversion Symmetry in a Metallic Double Perovskite, Pb2NiOsO6citations
- 2018Fatigue performances of FSW and GMAW aluminum alloys welded joints: Competition between microstructural and structural-contact-fretting crack initiationcitations
- 2018Fatigue performances of FSW and GMAW aluminum alloys welded joints: Competition between microstructural and structural-contact-fretting crack initiationcitations
- 2017Spatial GR4J conceptualization of the Tamor glaciated alpine catchment in Eastern Nepal: Evaluation of GR4JSG against streamflow and MODIS snow extentcitations
- 2017Strong, ductile, and thermally stable Cu-based metal-intermetallic nanostructured compositescitations
- 2008Formation of a low energy grain boundary in ZnO: The structural unit concept in hexagonal symmetry materialscitations
- 2004A cooperative benchmark effort on testing of woven composites
Places of action
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article
Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>We conducted observational and Mendelian randomization (MR) analyses to explore the associations between blood proteins and risk of peripheral artery disease (PAD).</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>The observational cohort analyses included data on 257 proteins estimated in fasting blood samples from 12 136 Swedish adults aged 55–94 years who were followed up for incident PAD via the Swedish Patient Register. Mendelian randomization analyses were undertaken using cis-genetic variants strongly associated with the proteins as instrumental variables and genetic association summary statistic data for PAD from the FinnGen study (11 924 cases and 288 638 controls) and the Million Veteran Program (31 307 cases and 211 753 controls). The observational analysis, including 86 individuals diagnosed with incident PAD during a median follow-up of 6.6-year, identified 13 proteins [trefoil factor two, matrix metalloproteinase-12 (MMP-12), growth differentiation factor 15, V-set and immunoglobulin domain-containing protein two, N-terminal prohormone brain natriuretic peptide, renin, natriuretic peptides B, phosphoprotein associated with glycosphingolipid-enriched microdomains one, C-C motif chemokine 15, P-selectin, urokinase plasminogen activator surface receptor, angiopoietin-2, and C-type lectin domain family five member A] associated with the risk of PAD after multiple testing correction. Mendelian randomization analysis found associations of T-cell surface glycoprotein CD4, MMP-12, secretoglobin family 3A member 2, and ADM with PAD risk. The observational and MR associations for T-cell surface glycoprotein CD4 and MMP-12 were in opposite directions.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This study identified many circulating proteins in relation to the development of incident PAD. Future studies are needed to verify our findings and assess the predictive and therapeutic values of these proteins in PAD.</jats:p></jats:sec>