| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Liu, Jun
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2024Role of Solvent in the Oriented Growth of Conductive Ni‐CAT‐1 Metal‐Organic Framework at Solid–Liquid Interfaces
- 2023Plasma-induced energy band evolution for two-dimensional heterogeneous anti-ambipolar transistorscitations
- 2023Damage and energy absorption behaviour of composite laminates under impact loading using different impactor geometriescitations
- 2023Modelling the effects of patch-plug configuration on the impact performance of patch-repaired composite laminatescitations
- 2023Non-destructive evaluation of magnetic anisotropy associated with crystallographic texture of interstitial free steelscitations
- 2023Non-destructive evaluation of magnetic anisotropy associated with crystallographic texture of interstitial free steelscitations
- 2023Machine learning on spectral data from miniature devices for food quality analysis - a case study
- 2022Non-destructive evaluation of magnetic anisotropy associated with crystallographic texture of interstitial free steels using an electromagnetic sensor
- 2020Wurtzite materials in alloys of rock salt compoundscitations
- 2019Magnetic characterisation of grain size and precipitate distribution by major and minor BH loop measurementscitations
- 2017Optimized setup and protocol for magnetic domain imaging with in Situ hysteresis measurementcitations
- 2017Mild oxalic-acid-catalyzed hydrolysis as a novel approach to prepare cellulose nanocrystalscitations
- 2017Spatial Control of Functional Response in 4D-Printed Active Metallic Structurescitations
- 2016Brush-painting and photonical sintering of copper and silver inks on cotton fabric to form antennas for wearable ultra-high-frequency radio-frequency identification tagscitations
- 2016Development of nanocellulose scaffolds with tunable structures to support 3D cell culturecitations
- 2015Tailor-made hemicellulose-based hydrogels reinforced with nanofibrillated cellulosecitations
- 2015Electromagnetic evaluation of the microstructure of grade 91 tubes/pipescitations
- 2015Binding kinetics of lock and key colloidscitations
- 2015Conductivity of PEDOT:PSS on spin-coated and drop cast nanofibrillar cellulose thin filmscitations
- 2014Differential permeability behaviour of P9 and T22 power station Steelscitations
- 2014Assessment of microstructural changes in Grade 91 power station tubes through incremental permeability and magnetic Barkhausen noise measurements
- 2014Biocomposites of Nanofibrillated Cellulose, Polypyrrole, and Silver Nanoparticles with Electroconductive and Antimicrobial Propertiescitations
- 2014Incremental permeability and magnetic Barkhausen noise for the assessment of microstructural changes in Grade 91 power station tubes
- 2013Magnetic evaluation of microstructure changes in 9Cr-1Mo and 2.25Cr-1Mo steels using electromagnetic sensorscitations
- 2008Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancercitations
Places of action
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article
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer
Abstract
Aromatic amines, N-nitroso compounds and heterocyclic amines are suspected human pancreatic carcinogens. Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens. To test the hypothesis that genetic variations in carcinogen metabolism modify the risk of pancreatic cancer (PC), we investigated the effect of single-nucleotide polymorphisms (SNPs) of the CYP1A2, NAT1, NAT2 and SULT1A1 gene on modification of the risk of PC in a hospital-based study of 755 patients with pancreatic adenocarcinoma and 636 healthy frequency-matched controls. Smoking and dietary mutagen exposure information was collected by personal interviews. Genotypes were determined using the polymerase chain reaction-restriction fragment length polymorphism and Taqman methods. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multivariate logistic regression analysis. We observed no significant main effects of any of these genes on the risk of PC. The CYP1A2 and NAT1 but not SULT1A1 and NAT2 genotypes showed significant interactions with heavy smoking in women not men. In contrast, a significant interaction between NAT1 genotype and dietary mutagen intake on modifying the risk of PC were observed among men but not women. The OR (95% CI) of PC was 2.23 (1.33-3.72) and 2.54 (1.51-4.25) for men having the NAT1*10 and a higher intake of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and benzo[a]pyrene, respectively, compared with individuals having no NAT1*10 or a lower intake of these dietary mutagens. These data suggest the existence of gender-specific susceptibility to tobacco carcinogen and dietary mutagen exposure in PC.