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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Łukowicz, Krzysztof
Jagiellonian University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (4/4 displayed)
- 2021Microstructure and in vitro evaluation of extruded and hot drawn alloy MgCa0.7 for biodegradable surgical wirescitations
- 2020Properties of scaffolds based on chitosan and collagen with bioglass 45S5citations
- 2019New insights into the PLGA and PCL blending: physico-mechanical properties and cell responsecitations
- 2017Characterization of gelatin and chitosan scaffolds cross-linked by addition of dialdehyde starchcitations
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article
New insights into the PLGA and PCL blending: physico-mechanical properties and cell response
Abstract
We examined the effects of blending of biodegradable polymers PCL and PLGA on their surface properties, crystallinity, mechanical parameters and in vitro cell response. Blends were fabricated in the form of films with the solvent casting method by combining 25-75 vol% of PCL with PLGA. Due to differences in morphology and surface properties of the opposite film sites, we investigated either air exposed (AS) or glass exposed (GS) surfaces. PCL-PLGA films showed differences in contact angle values, roughness parameters, morphology, cell growth and ALP activity depending whether the AS or GS was investigated. PCL-PLGA blends displayed enhanced roughness (i.e. AS), hydrophilicity and improved tensile properties when compared to neat PCL. Increasing PLGA content resulted in increased tensile strength and Young's modulus values of blends. Furthermore, the GS of blends favored cell growth, whereas AS increased cellular ALP activity. Thus, PCL and PLGA blending provide controllable physico-chemical properties and cell response depending on AS versus GS surface and PCL/PLGA ratio. © 2019 IOP Publishing Ltd.