| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Perriman, Adam Willis
University of Bristol
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2024Flax fibre reinforced alginate poloxamer hydrogelcitations
- 2023A rapid high throughput bioprinted colorectal cancer spheroid platform for in vitro drug- and radiation-responsecitations
- 2023Bienzymatic Generation of Interpenetrating Polymer Networked Engineered Living Materials with Shape Changing Propertiescitations
- 2023Design space and manufacturing of programmable 4D printed continuous flax fibre polylactic acid composite hygromorphscitations
- 2022The influence of the humidity on the mechanical properties of 3D printed continuous flax fibre reinforced poly(lactic acid) compositescitations
- 2022The Design of 4D-Printed Hygromorphscitations
- 2021Multiphase lattice metamaterials with enhanced mechanical performancecitations
- 2021Three-Dimensional Printable Enzymatically Active Plasticscitations
- 2020Chondroinduction of Mesenchymal Stem Cells on Cellulose-Silk Composite nanofibrous Substratescitations
- 2020Cactus-based solids and bio-composites for energy dissipation in defence and biomedical applications.
- 2020Abnormal stiffness behaviour in artificial cactus-inspired reinforcement materialscitations
- 2019A Composite Hydrogel Scaffold Permits Self‐Organization and Matrix Deposition by Cocultured Human Glomerular Cellscitations
- 2019Sequential Electrostatic Assembly of a Polymer Surfactant Corona Increases Activity of the Phosphotriesterase arPTEcitations
- 2017Mechanics and band gaps in hierarchical auxetic rectangular perforated composite metamaterialscitations
- 2014Molecular dynamics simulations reveal a dielectric-responsive coronal structure in protein-polymer surfactant hybrid nanoconstructscitations
- 2012Polymer/nucleotide droplets as bio-inspired functional micro-compartmentscitations
- 2009Membrane stabilization and transformation in organoclay-vesicle hybrid constructscitations
Places of action
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article
A rapid high throughput bioprinted colorectal cancer spheroid platform for in vitro drug- and radiation-response
Abstract
<jats:title>Abstract</jats:title><jats:p>We describe the development of a high-throughput bioprinted colorectal cancer (CRC) spheroid platform with high levels of automation, information content, and low cell number requirement. This is achieved via the formulation of a hydrogel bioink with a compressive Young’s modulus that is commensurate with that of colonic tissue (1–3 kPa), which supports exponential growth of spheroids from a wide range of CRC cell lines. The resulting spheroids display tight cell–cell junctions, bioink matrix-cell interactions and necrotic hypoxic cores. By combining high content light microscopy imaging and processing with rapid multiwell plate bioprinting, dose-response profiles are generated from CRC spheroids challenged with oxaliplatin (OX) and fluorouracil (5FU), as well as radiotherapy. Bioprinted CRC spheroids are shown to exhibit high levels of chemoresistance relative to cell monolayers, and OX was found to be significantly less effective against tumour spheroids than in monolayer culture, when compared to 5FU.</jats:p>