| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mota, Carlos
European Commission
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (27/27 displayed)
- 2024Upcycling Fishing Net Waste and Metal Oxide from Electroplating Waste into Alga Cultivation Structures with Antibacterial Properties
- 2023Blast fragment impact of angle-ply composite structures for buildings wall protectioncitations
- 2023Chitin nanofibrils modulate mechanical response in tympanic membrane replacementscitations
- 2023Matrix metalloproteinase degradable, in situ photocrosslinked nanocomposite bioinks for bioprinting applicationscitations
- 2022Advanced Coatings of Polyureas for Building Blast Protection: Physical, Chemical, Thermal and Mechanical Characterizationcitations
- 2021Shaping and properties of thermoplastic scaffolds in tissue regeneration: The effect of thermal history on polymer crystallization, surface characteristics and cell fatecitations
- 2021Additive manufactured scaffolds for bone tissue engineering: Physical characterization of thermoplastic composites with functional fillerscitations
- 2021Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineeringcitations
- 2021Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillerscitations
- 2021Controllable four axis extrusion-based additive manufacturing system for the fabrication of tubular scaffolds with tailorable mechanical propertiescitations
- 2021Chitin Nanofibril Application in Tympanic Membrane Scaffolds to Modulate Inflammatory and Immune Responsecitations
- 2021Study of the Filtration Performance of Multilayer and Multiscale Fibrous Structurescitations
- 2019Conception and characterization of different properties from a composite thermoformable with polymeric matrix and cellulosic fibres
- 2018Characterization of recycled carbon fibers reinforcing thermoplastic polymers
- 2018Influence of carbon nanotubes in the performance of a composite materials for ballistic helmets
- 2017Additive manufacturing of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] scaffolds for engineered bone developmentcitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regenerationcitations
- 2016Pseudo-ductile Braided Composite Rods (BCRs) produced by braidtrusion
- 2015Mechanical characterization of bio-epoxy ecocomposites reinforced with fibrous structures based on natural fibers
- 2015Processing and characterization of plates made from granulate of waste electrical cables
- 2015Mechanical properties of polypropylene/natural fiber composites: comparison with glass fiber
- 2014Estudo da adesão entre os materiais que constituem uma estrutura compósitas multicamada
- 2014Desenvolvimento e caracterização de varões compósitos híbridos para reforço de betão
- 2014Desenvolvimento de painéis compósitos multicamada com propriedades de resistência ao fogo
- 2014Development of multi-layer fibrous composites for fire resistant and sound insulating doors
- 2014Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer modelscitations
Places of action
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article
Surface energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regeneration
Abstract
Swift progress in biofabrication technologies has enabled unprecedented advances in the application of developmental biology design criteria in three-dimensional scaffolds for regenerative medicine. Considering that tissues and organs in the human body develop following specific physico-chemical gradients, in this study, we hypothesized that additive manufacturing (AM) technologies would significantly aid in the construction of 3D scaffolds encompassing such gradients. Specifically, we considered surface energy and stiffness gradients and analyzed their effect on adult bone marrow derived mesenchymal stem cell differentiation into skeletal lineages. Discrete step-wise macroscopic gradients were obtained by sequentially depositing different biodegradable biomaterials in the AM process, namely poly(lactic acid) (PLA), polycaprolactone (PCL), and poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) copolymers. At the bulk level, PEOT/PBT homogeneous scaffolds supported a higher alkaline phosphatase (ALP) activity compared to PCL, PLA, and gradient scaffolds, respectively. All homogeneous biomaterial scaffolds supported also a significantly higher amount of glycosaminoglycans (GAGs) production compared to discrete gradient scaffolds. Interestingly, the analysis of the different material compartments revealed a specific contribution of PCL, PLA, and PEOT/PBT to surface energy gradients. Whereas PEOT/PBT regions were associated to significantly higher ALP activity, PLA regions correlated with significantly higher GAG production. These results show that cell activity could be influenced by the specific spatial distribution of different biomaterial chemistries in a 3D scaffold and that engineering surface energy discrete gradients could be considered as an appealing criterion to design scaffolds for osteochondral regeneration.