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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gough, Julie
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2019Co-electrospraying of tumour cell mimicking hollow polymeric microspheres for diffusion magnetic resonance imagingcitations
- 2015Mechanical properties of porous ceramic scaffolds: Influence of internal dimensionscitations
- 2015Mechanical properties of porous ceramic scaffolds: Influence of internal dimensions:Influence of Internal Dimensionscitations
- 2014Enzymatically triggered peptide hydrogels for 3D cell encapsulation and culturecitations
- 2012Gel-cast glass-ceramic tissue scaffolds of controlled architecture produced via stereolithography of mouldscitations
- 2011Mechanosensitive peptide gelation: Mode of agitation controls mechanical properties and nano-scale morphologycitations
- 2009Introducing chemical functionality in Fmoc-peptide gels for cell culturecitations
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article
Gel-cast glass-ceramic tissue scaffolds of controlled architecture produced via stereolithography of moulds
Abstract
Two glass-ceramic scaffolds with a simple cubic structure of 500m square ligaments and square channels of width 400 or 600m have been fabricated by gel-casting into moulds produced by stereolithography, followed by mould removal, polymer burnout and sintering. The scaffolds have crushing strengths of 41 ± 14 and 17 ± 5 Mpa, respectively. Using a method of assembling discrete slices of scaffold, we are able to study cell behaviour within a scaffold by disassembly. Both scaffold structures were seeded with primary human osteoblasts and these penetrate, adhere, spread and proliferate on the scaffold structure. The larger channel diameter scaffold shows a greater cell population (despite its smaller surface area) and more pronounced production of ECM components (collagen and mineralization) with increased time in culture. Studies of sectioned scaffolds show that cell density and ECM production decrease with depth and that the difference between the two scaffold architectures is maintained. © 2012 IOP Publishing Ltd.