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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kojić, Vesna
Oncology Institute of Vojvodina
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024Electrochemically synthesized biomaterials
- 2024Electrochemically synthesized biocomposite poly(vinyl alcohol)/chitosan-based coatings for medical applications
- 2023Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defectscitations
- 2023Single-step, electrophoretically deposited hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coating for biomedical applicationscitations
- 2023Ultrafine-grained microstructure effect on the biomedical Ti-based alloy performance
- 2023Laser-modified Ti-45Nb alloy’s response to bio-environment
- 2023Hydroxyapatite/poly(vinyl alcohol)/chitosan coating with gentamicin for orthopedic implantscitations
- 2022Silver Nanoparticles-Loaded Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Obtained by Electrochemical Synthesis
- 2021Microstructural refinement influence on the Ti-45Nb alloy properties in physiological conditions ; Uticaj usitnjavanja mikrostrukture na svojstva Ti-45Nb legure u fiziološkim uslovima
- 2020Electrophoretically Deposited Bioceramic Composite Coatings on Ti Substrate Intended for Medical Use
- 2019Mg/Cu co-substituted hydroxyapatite – Biocompatibility, mechanical properties and antimicrobial activitycitations
- 2019Gentamicin-loaded bioceramic composite coating aimed for biomedical use
- 2018Bioactive Hydroxyapatite/Chitosan/Gentamicin Composite Coating Electrodeposited on Titanium
- 2018Selective anticancer activity of hydroxyapatite/chitosan-poly(D,L)-lactide-co-glycolide particles loaded with an androstane-based cancer inhibitorcitations
- 2018Selective anticancer activity of hydroxyapatite/chitosan-poly(D,L)-lactide-co-glycolide particles loaded with an androstane-based cancer inhibitorcitations
- 2018Improvement of Biocompatibility by Formation of Nanotubular Oxide Layer on the Ultrafine Grained Ti-13Nb-13Zr Alloy
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article
Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects
Abstract
<jats:title>Abstract</jats:title><jats:p>The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth of <jats:italic>Escherichia coli</jats:italic> and <jats:italic>Staphylococcus aureus</jats:italic> for 4–6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.</jats:p>