| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Teske, Michael
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2022Characterization of Ball-milled Poly(Nisopropylacrylamide) Nanogels
- 2022The influence of PEGDA’s molecular weight on its mechanical properties in the context of biomedical applicationscitations
- 2021A hydrogel based quasi-stationary test system for in vitro dexamethasone release studies for middle ear drug delivery systems
- 2020Smart releasing electrospun nanofibers-poly: L.lactide fibers as dual drug delivery system for biomedical application.citations
- 2020PEGDA drug delivery scaffolds manufactured with a novel hybrid AM process
- 20193D-printed PEGDA structure with multiple depots for advanced drug delivery systems
- 2019A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots. citations
- 2019Thermomechanical properties of PEGDA in combination with different photo-curable comonomerscitations
- 2019Controlled biodegradation of metallic biomaterials by plasma polymer coatings using hexamethyldisiloxane and allylamine monomerscitations
- 2018Thermomechanical properties of PEGDA and its co-polymerscitations
- 2018Novel approach for a PTX/VEGF dual drug delivery system in cardiovascular applications-an innovative bulk and surface drug immobilization.citations
- 2017Osteointegration of Porous Poly-ε-Caprolactone-Coated and Previtalised Magnesium Implants in Critically Sized Calvarial Bone Defects in the Mouse Model. citations
- 2017In Vitro Evaluation of PCL and P(3HB) as Coating Materials for Selective Laser Melted Porous Titanium Implants. citations
- 2017Influence of bulk incorporation of FDAc and PTX on polymer propertiescitations
- 2015Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL
- 2015Surface Modification of Biodegradable Polymers towards Better Biocompatibility and Lower Thrombogenicity.citations
- 2015Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL.citations
- 2015SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding.citations
Places of action
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article
Smart releasing electrospun nanofibers-poly: L.lactide fibers as dual drug delivery system for biomedical application.
Abstract
An ongoing challenge in drug delivery systems for a variety of medical applications, including cardiovascular diseases, is the delivery of multiple drugs to address numerous phases of a treatment or healing process. Therefore, an extended dual drug delivery system (DDDS) based on our previously reported cardiac DDDS was generated. Here we use the polymer poly(L-lactide) (PLLA) as drug carrier with the cytostatic drug Paclitaxel (PTX) and the endothelial cell proliferation enhancing growth factor, human vascular endothelial growth factor (VEGF), to overcome typical in-stent restenosis complications. We succeeded in using one solution to generate two separate DDDS via spray coating (film) and electrospinning (nonwoven) with the same content of PTX and the same post processing for VEGF immobilisation. Both processes are suitable as coating techniques for implants. The contact angle analysis revealed differences between films and nonwovens. Whereas, the morphological analysis demonstrated nearly no changes occurred after immobilisation of both drugs. Glass transition temperatures (T<sub>g</sub> ) and degree of crystallinity (χ) show only minor changes. The amount of immobilised VEGF on nonwovens was over 300% higher compared to the films. Also, the nonwovens revealed a much faster and over three times higher PTX release over 70 d compared to the films. The almost equal physical properties of nonwovens and films allow the comparison of both DDDS independently of their fabrication process. Both films and nonwovens have significantly increased in vitro cell viability for human umbilical vein endothelial cells (EA.hy926) with dual loaded PTX and VEGF compared to PTX-only loaded samples.