| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Penta, Raimondo
University of Glasgow
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2023Effective governing equations for dual porosity Darcy–Brinkman systems subjected to inhomogeneous body forces and their application to the lymph nodecitations
- 2023Investigating the effects of microstructural changes induced by myocardial infarction on the elastic parameters of the heartcitations
- 2020Effective balance equations for poroelastic compositescitations
- 2020A hierarchical asymptotic homogenization approach for viscoelastic compositescitations
- 2019Effective properties of hierarchical fiber-reinforced composites via a three-scale asymptotic homogenization approachcitations
- 2019The role of porosity and solid matrix compressibility on the mechanical behavior of poroelastic tissuescitations
- 2019Macroscopic thermal profile of heterogeneous cancerous breasts. A three-dimensional multiscale analysiscitations
- 2019Homogenized out-of-plane shear response of three-scale fiber-reinforced compositescitations
- 2019Homogenized out-of-plane shear response three-scale fiber-reinforced compositescitations
- 2019An approach for modeling non-ageing linear viscoelastic composites with general periodicitycitations
- 2017The asymptotic homogenization elasticity tensor properties for composites with material discontinuitiescitations
- 2016Can a continuous mineral foam explain the stiffening of aged bone tissue? A micromechanical approach to mineral fusion in musculoskeletal tissuescitations
Places of action
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article
Can a continuous mineral foam explain the stiffening of aged bone tissue? A micromechanical approach to mineral fusion in musculoskeletal tissues
Abstract
Recent experimental data revealed a stiffening of aged cortical bone tissue, which could not be explained by common multiscale elastic material models. We explain this data by incorporating the role of mineral fusion via a new hierarchical modeling approach exploiting the asymptotic (periodic) homogenization (AH) technique for three-dimensional linear elastic composites. We quantify for the first time the stiffening that is obtained by considering a fused mineral structure in a softer matrix in comparison with a composite having non-fused cubic mineral inclusions. We integrate the AH approach in the Eshelby-based hierarchical mineralized turkey leg tendon model (Tiburtius et al 2014 Biomech. Model. Mechanobiol. 13 1003–23), which can be considered as a base for musculoskeletal mineralized tissue modeling. We model the finest scale compartments, i.e. the extrafibrillar space and the mineralized collagen fibril, by replacing the self-consistent scheme with our AH approach. This way, we perform a parametric analysis at increasing mineral volume fraction, by varying the amount of mineral that is fusing in the axial and transverse tissue directions in both compartments. Our effective stiffness results are in good agreement with those reported for aged human radius and support the argument that the axial stiffening in aged bone tissue is caused by the formation of a continuous mineral foam. Moreover, the proposed theoretical and computational approach supports the design of biomimetic materials which require an overall composite stiffening without increasing the amount of the reinforcing material.