| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Markos, Christos
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (46/46 displayed)
- 2023Drug delivery and optical neuromodulation using a structured polymer optical fiber with ultra-high NA
- 2023Optoelectronic and mechanical properties of microstructured polymer optical fiber neural probescitations
- 2023In vivo brain temperature mapping using polymer optical fiber Bragg grating sensorscitations
- 2022Adaptive polymer fiber neural device for drug delivery and enlarged illumination angle for neuromodulationcitations
- 20222 um Raman laser based on CO 2 -filled hollow-core silica fiber
- 2022Microstructured soft fiber-based neural device for drug delivery and optical neuromodulationcitations
- 20222 um Raman laser based on CO2-filled hollow-core silica fiber
- 2021Influence of Thermo-Mechanical Mismatch when Nanoimprinting Anti-Reflective Structures onto Small-core Mid-IR Chalcogenide Fibers
- 2021Thermo-mechanical dynamics of nanoimprinting anti-reflective structures onto small-core mid-IR chalcogenide fiberscitations
- 2021Thermo-mechanical Dynamics of Nanoimprinting Anti-Reflective Structures onto Small-core Mid- IR Chalcogenide Fibers
- 2021High-temperature polymer multimaterial fiberscitations
- 2020All-polymer multimaterial optical fiber fabrication for high temperature applicationscitations
- 2019Single-mode, low loss hollow-core antiresonant fiber designscitations
- 2019Microstructured Polymer Optical Fiber Gratings and Sensorscitations
- 2018Direct nanoimprinting of moth-eye structures in chalcogenide glass for broadband antireflection in the mid-infraredcitations
- 2018Multimaterial photonic crystal fiberscitations
- 2017Reconfigurable opto-thermal graded-index waveguiding in bulk chalcogenide glassescitations
- 2017Multiple soliton compression stages in mid-IR gas-filled hollow-core fibers
- 2017Zeonex microstructured polymer optical fiber: fabrication friendly fibers for high temperature and humidity insensitive Bragg grating sensingcitations
- 2017Simultaneous measurement of temperature and humidity with microstructured polymer optical fiber Bragg gratingscitations
- 2017Low Loss Polycarbonate Polymer Optical Fiber for High Temperature FBG Humidity Sensingcitations
- 2017Toward single-mode UV to near-IR guidance using hollow-core antiresonant silica fibercitations
- 2017Toward single-mode UV to near-IR guidance using hollow-core antiresonant silica fibercitations
- 2017Zeonex-PMMA microstructured polymer optical FBGs for simultaneous humidity and temperature sensingcitations
- 2016Characterising refractive index dispersion in chalcogenide glassescitations
- 2016Single mode step-index polymer optical fiber for humidity insensitive high temperature fiber Bragg grating sensorscitations
- 2016Zeonex Microstructured Polymer Optical Fibre Bragg Grating Sensorcitations
- 2016Fabrication and characterization of polycarbonate microstructured polymer optical fibers for high-temperature-resistant fiber Bragg grating strain sensorscitations
- 2016Thermo-tunable hybrid photonic crystal fiber based on solution-processed chalcogenide glass nanolayerscitations
- 2016Temperature insensitive hysteresis free highly sensitive polymer optical fiber Bragg grating humidity sensorcitations
- 2016Creation of a microstructured polymer optical fiber with UV Bragg grating inscription for the detection of extensions at temperatures up to 125°Ccitations
- 2016Polymer Optical Fibre Bragg Grating Humidity Sensor at 100ºC
- 2015Humidity insensitive step-index polymer optical fibre Bragg grating sensorscitations
- 2015Production and Characterization of Polycarbonate Microstructured Polymer Optical Fiber Bragg Grating Sensor
- 2015Antiresonant guiding in a poly(methyl-methacrylate) hollow-core optical fibercitations
- 2015Thermally tunable bandgaps in a hybrid As2S3/silica photonic crystal fibercitations
- 2014PMMA mPOF Bragg gratings written in less than 10 mincitations
- 2014Photo-induced changes in a hybrid amorphous chalcogenide/silica photonic crystal fibercitations
- 2014THz waveguides, devices and hybrid polymer-chalcogenide photonic crystal fibers
- 2014Hybrid polymer photonic crystal fiber with integrated chalcogenide glass nanofilmscitations
- 2014Bragg grating writing in PMMA microstructured polymer optical fibers in less than 7 minutescitations
- 2014THz Waveguides, Devices and Hybrid Polymer-chalcogenidePhotonic Crystal Fibers
- 2013High-Tg TOPAS microstructured polymer optical fiber for fiber Bragg grating strain sensing at 110 degreescitations
- 2013High-T g TOPAS microstructured polymer optical fiber for fiber Bragg grating strain sensing at 110 degreescitations
- 2011Narrow Bandwidth 850-nm Fiber Bragg Gratings in Few-Mode Polymer Optical Fiberscitations
- 2011Label-free biosensing with high sensitivity in dual-core microstructured polymer optical fiberscitations
Places of action
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article
Adaptive polymer fiber neural device for drug delivery and enlarged illumination angle for neuromodulation
Abstract
Optical fiber devices constitute significant tools for the modulation and interrogation of neuronal circuitry in the mid and deep brain regions. The illuminated brain area during neuromodulation has a direct impact on the spatio-temporal properties of the brain activity and depends solely on the material and geometrical characteristics of the optical fibers. In the present work, we developed two different flexible polymer optical fibers (POFs) with integrated microfluidic channels (MFCs) and an ultra-high numerical aperture (UHNA) for enlarging the illumination angle to achieve efficient neuromodulation. <jats:italic>Approach</jats:italic>. Three distinct thermoplastic polymers: polysulfone, polycarbonate, and fluorinated ethylene propylene were used to fabricate two step-index UHNA POF neural devices using a scalable thermal drawing process. The POFs were characterized in terms of their illumination map as well as their fluid delivery capability in phantom and adult rat brain slices<jats:italic>. Main results.</jats:italic> A 100-fold reduced bending stiffness of the proposed fiber devices compared to their commercially available counterparts has been found. The integrated MFCs can controllably deliver dye (trypan blue) on-demand over a wide range of injection rates spanning from 10 nl min<jats:sup>−1</jats:sup> to 1000 nl min<jats:sup>−1</jats:sup>. Compared with commercial silica fibers, the proposed UHNA POFs exhibited an increased illumination area by 17% and 21% under 470 and 650 nm wavelength, respectively. In addition, a fluorescent light recording experiment has been conducted to demonstrate the ability of our UHNA POFs to be used as optical waveguides in fiber photometry. <jats:italic>Significance</jats:italic>. Our results overcome the current technological limitations of fiber implants that have limited illumination area and we suggest that soft neural fiber devices can be developed using different custom designs for illumination, collection, and photometry applications. We anticipate our work to pave the way towards the development of next-generation functional optical fibers for neuroscience.</jats:p>