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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Madsen, Frederikke Bahrt
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (39/39 displayed)
- 2024Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoidscitations
- 2023Antimicrobial silicone skin adhesives facilitated by controlled octenidine release from glycerol compartmentscitations
- 2022A reliable quantitative method for determining CBD content and release from transdermal patches in Franz cellscitations
- 2021Glycerol‐Filled Silicone Adhesive Patches with Excellent Sun Protectioncitations
- 2019Glycerol-silicone foams - Tunable 3-phase elastomeric porous materialscitations
- 2018Degradation patterns of silicone-based dielectric elastomers in electrical fieldscitations
- 2016Silicone elastomers with superior softness and dielectric properties
- 2016Bimodal condensation silicone elastomers as dielectric elastomers
- 2016Self-Healing, High-Permittivity Silicone Dielectric Elastomercitations
- 2016A simple method for reducing inevitable dielectric loss in high-permittivity dielectric elastomerscitations
- 2016The Current State of Silicone-Based Dielectric Elastomer Transducerscitations
- 2016Molecular beam deposition of high-permittivity polydimethylsiloxane for nanometer-thin elastomer films in dielectric actuatorscitations
- 2016Molecular beam deposition of high-permittivity polydimethylsiloxane for nanometer-thin elastomer films in dielectric actuatorscitations
- 2016Mechanically compliant electrodes and dielectric elastomers from PEG-PDMS copolymers
- 2016Mechanical and Electrical Ageing Effects on the Long-Term Stretching of Silicone Dielectric Elastomers with Soft Fillers:Long-Term Stretching of Silicone Dielectric Elastomerscitations
- 2015A new soft dielectric silicone elastomer matrix with high mechanical integrity and low lossescitations
- 2015Super soft silicone elastomers with high dielectric permittivitycitations
- 2015High energy density interpenetrating networks from ionic networks and siliconecitations
- 2015Dielectric elastomers, with very high dielectric permittivity, based on silicone and ionic interpenetrating networkscitations
- 2015Functional silicone elastomers via novel siloxane copolymers and chain extenders
- 2015Functional silicone copolymers and elastomers with high dielectric permittivity
- 2015Silicone chain extender
- 2015Soft Functional Silicone Elastomers with High Dielectric Permittivty: Simple Additives vs. Cross-Linked Synthesized Copolymers
- 2015Silicone elastomers with high dielectric permittivity and high dielectric breakdown strength based on tunable functionalized copolymerscitations
- 2014Synthetic Strategies for High Dielectric Constant Silicone Elastomers
- 2014Synthetic Strategies for High Dielectric Constant Silicone Elastomers
- 2014Silicone elastomers with high dielectric permittivity and high dielectric breakdown strength based on dipolar copolymerscitations
- 2013Novel silicone compatible cross-linkers for controlled functionalization of PDMS networkscitations
- 2013Novel cross-linkers for PDMS networks for controlled and well distributed grafting of functionalities by click chemistrycitations
- 2013Silicone resembling poly (propylene glycol) interpenetrating networks based on no pre-stretch as basis for electrical actuatorscitations
- 2013Dipolar cross-linkers for PDMS networks with enhanced dielectric permittivity and low dielectric losscitations
- 2013Intelligente materialer som kunstige muskler og energi-høstere
- 2013Development of novel PDMS elastomers for dielectric electroactive polymers (DEAPs)
- 2012New Cross-linkers for PDMS Networks
- 2012Development of new PDMS based materials for dielectric electroactive polymers (DEAPs) as actuators and generators
- 2012Udvikling af materialer til kunstige muskler
- 2012Novel silicone compatible cross-linkers for controlled and well distributed functionalization of PDMS networks
- 2012Bimodal Networks as Candidates for Electroactive Polymers
- 2011New Cross-linkers for PDMS Networks
Places of action
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article
Antimicrobial silicone skin adhesives facilitated by controlled octenidine release from glycerol compartments
Abstract
For improved wound healing, antimicrobial adhesives are one path forward. However, with the current challenge of bacterial resistance, it is essential to choose the included drug carefully. Octenidine is an obvious choice due to its broad antimicrobial efficacy and no reported bacterial resistance. In its pure form, octenidine complexes efficiently with the platinum catalyst in the silicone composition, inhibiting the targeted hydrosilylation reaction and hindering curing. This obstacle is overcome by screening octenidine with cyclodextrins in homogeneously dispersed glycerol droplets, suppressing Pt inhibition in the silicone phase. Curing efficiency is demonstrated using rheology, which shows that it is possible to incorporate one wt% of octenidine into glycerol–silicone adhesives in the presence of (2-hydroxypropyl)-β-cyclodextrin without affecting the adhesives’ mechanical properties. The interaction between octenidine and (2-hydroxypropyl)-β-cyclodextrin through an inclusion complex is confirmed by ROESY spectroscopy. Despite this screening, octenidine is still released efficiently from the glycerol–silicone adhesives upon contact with water, and the resulting antimicrobial action is subsequently demonstrated. This new technology constitutes a simple and efficient method for preparing wound care adhesives that actively inhibit the growth of four bacteria strains and one fungus.