| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Casati, R. |
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| Kočí, Jan | Prague |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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Agger, Else M.
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article
Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres
Abstract
The ability of liposomes and microspheres to enhance the efficacy of asub-unit antigen was investigated. Microspheres were optimised bytesting a range of surfactants employed in the external aqueous phaseof a water-in-oil-in-water (w/o/w) double emulsion solvent evaporationprocess for the preparation of microspherescomposed ofpoly(d,l-lactide-co-glycolide) and the immunological adjuvant dimethyldioctadecyl ammonium bromide (DDA)and then investigated with regard tothe physico-chemical and immunological characteristics of the particlesproduced. The results demonstrate that this parameter can affect thephysico-chemical characteristics of these systems and subsequently, hasa substantial bearing on the level of immune response achieved, bothhumoural and cell mediated, when employed for the delivery of thesub-unit tuberculosis vaccine antigen Ag85B-ESAT-6. Moreover, themicrosphere preparations investigated failed to initiate immuneresponses at the levels achieved with an adjuvant DDA-based liposomeformulation (DDA-TDB), further substantiating the superior ability ofliposomes as vaccine delivery systems.