| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Sefcik, Jan
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023Machine Learning-Derived Correlations for Scale-Up and Technology Transfer of Primary Nucleation Kinetics.
- 2023Machine learning derived correlations for scale-up and technology transfer of primary nucleation kineticscitations
- 2019Measuring secondary nucleation through single crystal seedingcitations
- 2018Enabling precision manufacturing of active pharmaceutical ingredientscitations
- 2017Kinetics of early stages of resorcinol-formaldehyde polymerization investigated by solution phase nuclear magnetic resonance spectroscopycitations
- 2013250 nm glycine-rich nanodroplets are formed on dissolution of glycine crystals but are too small to provide productive nucleation sitescitations
- 2011Structure of laponite-styrene precursor dispersions for production of advanced polymer-clay nanocompositescitations
- 2009Characterization of arsenic-rich waste slurries generated during GaAs wafer lapping and polishing
- 2008Formation of valine microcrystals through rapid antisolvent precipitationcitations
- 2003Monte Carlo simulations of size and structure of gel precursors in silica polycondensationcitations
Places of action
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article
Formation of valine microcrystals through rapid antisolvent precipitation
Abstract
In this work we have experimentally studied concentration effects on antisolvent precipitation of valine (an amino acid) from aqueous isopropanol solutions. Our experiments showed that the valine precipitation is very sensitive to both the supersaturation and to the water content in the final solution. Results from spectrophotometric measurements and supersaturation analysis showed that the crystal formation kinetics are strongly dependent on both mixing and concentration profiles in the early stages of the process, even though no visible change in the systems occurs immediately upon mixing with the antisolvent or subsequent dilution. Results from small-angle static light scattering measurements showed that the first visible crystals are of micron size and they grow only little over time, while their number increases gradually. Taken together, these experiments point to intermediate phase separation of (possible amorphous) precursors, being either very small nanoparticles or droplets with their refractive index closely matching that of the continuous phase, which subsequently assemble into micron size valine crystals.