• Ryu, Hanjun
• Kim, Suyeon
• Lee, Jae Hee
• Ciatti, Joanna L.
• Yamagishi, Kento
• Ameer, Guillermo
• Madhvapathy, Surabhi R.
• Cheng, Earl Y.
• Halliday, Lisa C.
• Kwak, Jean Won
• Won, Sang Min
• Kini, Mitali
• Park, Do Yun
• Kim, Bosung
• Seo, Min-Ho
• Kwak, Sung Soo
• Yoo, Jae-Young
• Halstead, Nadia V.
• Bury, Matthew I.
• Yoon, Hong-Joon
• Kwon, Kyeongha
• Wu, Yunyun
• Sharma, Arun
• Rogers, John

Abstract

<jats:p>Partial cystectomy procedures for urinary bladder–related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.</jats:p>

Topics