| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Li, Jin
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2024Controlling Pt nanoparticle sintering by sub-monolayer MgO ALD thin filmscitations
- 2023Atomic layer deposition of yttrium oxide as a protective coating for lithium metal anodes
- 2022Titanium carboxylate molecular layer deposited hybrid films as protective coatings for lithium-ion batteriescitations
- 2021Autism-associated mutations in K <sub>V</sub> 7 channels induce gating pore currentcitations
- 2021Atomic layer deposition on polymer thin films : on the role of precursor infiltration and reactivitycitations
- 2021Covalent graphite modification by low-temperature photocatalytic oxidation using a titanium dioxide thin film prepared by atomic layer depositioncitations
- 2020Surfactant-laden bubble dynamics under porous polymer films.citations
- 2014Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography.citations
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article
Autism-associated mutations in K <sub>V</sub> 7 channels induce gating pore current
Abstract
<jats:title>Significance</jats:title><jats:p>Autism spectrum disorder (ASD) adversely impacts >1% of children, causing social interaction deficits, repetitive behaviors, and communication disorders. Genetic analysis of ASD has advanced dramatically through genome sequencing, which has identified >500 genes with mutations in ASD. Mutations in the voltage sensor of the voltage-gated potassium (K<jats:sub>V</jats:sub>) channel K<jats:sub>V</jats:sub>7 are frequently associated with ASD. We discovered that these ASD mutations cause an ionic leak through the voltage sensor, termed gating pore current. When these mutations were inserted into the genome of mouse dopamine neurons, they caused a dramatic alteration in the ability of those neurons to fire action potentials in response to electrical stimulation. These changes would impair information processing in neurons, leading to broad changes in brain function.</jats:p>