| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Thompson, Paul
University of Warwick
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2022Charge reorganization at the adsorbate covered electrode surface probed through in-situ resonant x-ray diffraction combined with ab initio modellingcitations
- 2021An updated investigation of the multidimensional structure of language lateralization in left- and right-handed adults: a test–retest functional transcranial Doppler sonography study with six language taskscitations
- 2020Solubility, speciation and local environment of chlorine in zirconolite glass-ceramics for the immobilisation of plutonium residuescitations
- 2020In Situ Electric-Field Study of Surface Effects in Domain Engineered Pb(In1/2Nb1/2)O-3-Pb(Mg1/3Nb2/3)O-3-PbTiO(3)Relaxor Crystals by Grazing Incidence Diffractioncitations
- 2018In situ simultaneous photovoltaic and structural evolution of perovskite solar cells during film formationcitations
- 2013Simultaneous measurement of X-ray powder diffraction and ferroelectric polarisation data as a function of applied electric field at a range of frequenciescitations
- 2012Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE genecitations
Places of action
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article
Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene
Abstract
Free to read at publisherControl of iron homeostasis is essential for healthy central nervous system function: iron deficiency is associated with cognitive impairment, yet iron overload is thought to promote neurodegenerative diseases. Specific genetic markers have been previously identified that influence levels of transferrin, the protein that transports iron throughout the body, in the blood and brain. Here, we discovered that transferrin levels are related to detectable differences in the macro- and microstructure of the living brain. We collected brain MRI scans from 615 healthy young adult twins and siblings, of whom 574 were also scanned with diffusion tensor imaging at 4 Tesla. Fiber integrity was assessed by using the diffusion tensor imaging-based measure of fractional anisotropy. In bivariate genetic models based on monozygotic and dizygotic twins, we discovered that partially overlapping additive genetic factors influenced transferrin levels and brain microstructure. We also examined common variants in genes associated with transferrin levels, TF and HFE, and found that a commonly carried polymorphism (H63D at rs1799945) in the hemochromatotic HFE gene was associated with white matter fiber integrity. This gene has a well documented association with iron overload. Our statistical maps reveal previously unknown influences of the same gene on brain microstructure and transferrin levels. This discovery may shed light on the neural mechanisms by which iron affects cognition, neurodevelopment, and neurodegeneration.