| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Nugent, Michael J. D.
Athlone Institute of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2024Extraction and characterization of microfibrillated cellulose (MFC) from Rhododendron ponticum isolated using cryocrush pre-treatment and its potential for mycelium cultivationcitations
- 2024Investigation of the effect of Graphene oxide concentration on the final properties of Aspirin loaded PLA filaments for drug delivery systems
- 2023Evaluation of titanium nitride coatings in bandsaw blades for wood splitting by cold plasmacitations
- 2022Plasma electrolytic oxidation up to four-steps performed on niobium and Nb-Ti alloyscitations
- 2021Scratch-resistant and well-adhered nanotube arrays produced via anodizing process on β-titanium alloycitations
- 2021Scratch-resistant and well-adhered nanotube arrays produced via anodizing process on β-titanium alloycitations
- 2021Ti-25Nb-25Ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applications
- 2021Ti-25nb-25ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applicationscitations
- 2021Development, characterization and cell viability inhibition of pva spheres loaded with doxorubicin and 4′-amino-1-naphthyl-chalcone (D14) for osteosarcomacitations
- 2021Evaluation of titanium nitride coatings in bandsaw blades for wood splitting by cold plasmacitations
- 2020Effect of cellulose size-concentration on the structure of polyvinyl alcohol hydrogelscitations
- 2020Titanium-Niobium (Ti-xNb) Alloys with High Nb Amounts for Applications in Biomaterialscitations
- 2019Titanium-niobium alloys covered by electrospinning technique to applications in bone implants
- 2019Electrospun hydrogels composites for bone tissue engineering.
- 2019The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system.citations
- 2019The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet systemcitations
- 2019Photopolymerization for filling porous ceramic matrixcitations
- 2018Electrospun hydrogels composites for bone tissue engineeringcitations
- 2013Effect of slight crosslinking on the mechanical relaxation behavior of poly(2-ethoxyethyl methacrylate) chainscitations
- 2009Development and characterisation of an agar-polyvinyl alcohol blend hydrogelcitations
- 2008Characterisation and controlled drug release from novel drug-loaded hydrogelscitations
- 2007The effect of salts and pH buffered solutions on the phase transition temperature and swelling of thermoresponsive pseudogels based on N-isopropylacrylamidecitations
- 2007The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
- 2007Preparation of a novel freeze thawed poly(vinyl alcohol) composite hydrogel for drug delivery applicationscitations
- 2006Lower critical solution temperature control and swelling behaviour of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
Places of action
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article
Investigation of the effect of Graphene oxide concentration on the final properties of Aspirin loaded PLA filaments for drug delivery systems
Abstract
<p>It is well established that Polylactic acid (PLA) based biodegradable implants have several advantages over nonbiodegradable implants. PLA based implants can be used for controlled drug release as well as for mechanical functions and they break down in vivo into nontoxic by-products that are naturally eliminated from the body. Unlike permanent implants, no additional surgical procedure is required for their removal. Despite the benefits, currently PLA based implants are used in limited applications compared to e.g., titanium-based implants. The issues associated with PLA based implants are their lower tensile strength, poor hydrophobicity, and poor bioactivity. Graphene oxide (GO) which is a 2D material, possess several unique features which can potentially be used to overcome these issues. Due to its high surface area, GO can enhance the mechanical properties of PLA. Furthermore, GO is rich with oxygen containing functional groups, so when used as a drug carrier it can enhance the biocompatibility of the drug, as well as the bioavailability and dissolution rate. One of the challenges associated with current drug delivery systems is limitations in the achievable drug loadings. The lamella structure of GO can facilitate higher loading of drug and can be used in applications where high loadings are essential e.g., cancer treatment. This work aims to investigate whether different loadings of GO can enhance the mechanical properties of a PLA-drug matrix along with investigating the effect of GO loadings on the drug dissolution rate. In this work, Aspirin was used as a model drug with PLA, and GO was used in three different loadings (0.25 wt.%, 0.5 wt.% and 1 wt.%). PLA-Aspirin and GO were processed using hot melt extrusion process. After processing, the effect of GO loadings on the mechanical properties, and drug release profile was studied. Scanning electron microscope (SEM) testing of the samples was carried out to investigate the dispersion of drug for different loadings of GO. GO tends to agglomerate into larger particles and this affects the mechanical properties and dissolution rate.</p>