| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mcafee, Marion
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2024Embedding a surface acoustic wave sensor and venting into a metal additively manufactured injection mould tool for targeted temperature monitoringcitations
- 2024Sensorised metal AM injection mould tools for in-process monitoring of cooling performance with conventional and conformal cooling channel designscitations
- 2024Investigation of the effect of Graphene oxide concentration on the final properties of Aspirin loaded PLA filaments for drug delivery systems
- 2023Enhancement of biodegradability of polylactides by γ-ray irradiation
- 2023Interpretable machine learning methods for monitoring polymer degradation in extrusion of polylactic acidcitations
- 2021Comparison of data summarization and feature selection techniques for in-process spectral datacitations
- 2018A soft sensor for prediction of mechanical properties of extruded PLA sheet using an instrumented slit die and machine learning algorithmscitations
- 2014The application of computational chemistry and chemometrics to developing a method for online monitoring of polymer degradation in the manufacture of bioresorbable medical implants
- 2012Water spray cooling of polymerscitations
- 2012Dynamic grey-box modeling for online monitoring of extrusion viscositycitations
- 2011The inferential monitoring of screw load torque to predict process fluctuations in polymer extrusioncitations
- 2011The inferential monitoring of the screw disturbance torque to predict process fluctuations in polymer extrusioncitations
- 2011Internal cooling in rotational molding-A reviewcitations
- 2011Quantitative characterization of clay dispersion in polymer-clay nanocompositescitations
- 2010Quantitative characterization of clay dispersion in polypropylene-clay nanocomposites by combined transmission electron microscopy and optical microscopy
- 2010Quantitative characterization of clay dispersion in polypropylene-clay nanocomposites by combined transmission electron microscopy and optical microscopycitations
- 2010Structure-property relationships in biaxially deformed polypropylene nanocompositescitations
- 2007Enhancing process insight in polymer extrusion by grey box modellingcitations
- 2007A novel approach to dynamic modelling of polymer extrusion for improved process controlcitations
- 2007A Soft Sensor for viscosity control of polymer extrusioncitations
- 2006Energy efficient extrusion
- 2003Design of a soft sensor for polymer extrusion
Places of action
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article
Investigation of the effect of Graphene oxide concentration on the final properties of Aspirin loaded PLA filaments for drug delivery systems
Abstract
<p>It is well established that Polylactic acid (PLA) based biodegradable implants have several advantages over nonbiodegradable implants. PLA based implants can be used for controlled drug release as well as for mechanical functions and they break down in vivo into nontoxic by-products that are naturally eliminated from the body. Unlike permanent implants, no additional surgical procedure is required for their removal. Despite the benefits, currently PLA based implants are used in limited applications compared to e.g., titanium-based implants. The issues associated with PLA based implants are their lower tensile strength, poor hydrophobicity, and poor bioactivity. Graphene oxide (GO) which is a 2D material, possess several unique features which can potentially be used to overcome these issues. Due to its high surface area, GO can enhance the mechanical properties of PLA. Furthermore, GO is rich with oxygen containing functional groups, so when used as a drug carrier it can enhance the biocompatibility of the drug, as well as the bioavailability and dissolution rate. One of the challenges associated with current drug delivery systems is limitations in the achievable drug loadings. The lamella structure of GO can facilitate higher loading of drug and can be used in applications where high loadings are essential e.g., cancer treatment. This work aims to investigate whether different loadings of GO can enhance the mechanical properties of a PLA-drug matrix along with investigating the effect of GO loadings on the drug dissolution rate. In this work, Aspirin was used as a model drug with PLA, and GO was used in three different loadings (0.25 wt.%, 0.5 wt.% and 1 wt.%). PLA-Aspirin and GO were processed using hot melt extrusion process. After processing, the effect of GO loadings on the mechanical properties, and drug release profile was studied. Scanning electron microscope (SEM) testing of the samples was carried out to investigate the dispersion of drug for different loadings of GO. GO tends to agglomerate into larger particles and this affects the mechanical properties and dissolution rate.</p>