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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Peters, Tj
in Cooperation with on an Cooperation-Score of 37%
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Publications (3/3 displayed)
- 2022A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac)citations
- 2016Using willingness-to-pay to establish patient preferences for cancer testing in primary carecitations
- 201610-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer.citations
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article
10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer.
Abstract
BackgroundThe comparative effectiveness of treatments for PSA-detected prostate cancer remains uncertain. The Prostate testing for cancer and Treatment (ProtecT) trial compared active monitoring, radical prostatectomy and external-beam radiotherapy treatment strategies for clinically localized disease.MethodsBetween 1999 and 2009, 82,429 men aged 50-69 years received a PSA test, 2,664 were diagnosed with localized prostate cancer and 1,643 agreed to randomization to active monitoring (n=545), radical prostatectomy (n=553) or radiotherapy (n=545). The primary end-point was prostate cancer mortality at 10-year median follow-up. Secondary outcomes included disease progression,metastases, and all-cause mortality.ResultsThere were no differences between the arms for 17 prostate cancer-specific (p=0.48) and 169 allcause (p=0.87) deaths. Eight men died of prostate cancer in the active monitoring arm (1.5 per-1000- person-years [p1000pyrs], 95% confidence interval [CI]: 0.7-3.0); 5 in the surgery arm (0.9 p1000pyrs; 95% CI: 0.4-2.2), and 4 in the radiotherapy arm (0.7 p1000pyrs; 95% CI: 0.3-2.0). Moremen developed metastases in the active monitoring arm (n=33; 6.3 p1000pyrs; 95% CI: 4.5-8.8), compared with surgery (n=13; 2.4 p1000pyrs; 1.4-4.2) and radiotherapy (n=16; 3.0 p1000pyrs; 95% CI: 1.9-4.9); p=0.004. Higher rates of disease progression occurred in the active monitoring arm (n=112; 22.9 p1000pyrs; 95% CI: 19.0-27.5) compared with surgery (n=46; 8.9 p1000pyrs; 95% CI: 6.7-11.9) and radiotherapy (n=46; 9.0 p1000pyrs; 95% CI: 6.7-12.0); p<0.001.ConclusionsAt a median of 10-years, prostate cancer-specific mortality was low irrespective of treatment assigned. Surgery and radiotherapy reduced disease progression and metastases. Further follow-up is required to ascertain if this confers long-term survival benefits.