| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Collins, Andrew
University of Southampton
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2010Assembly of poly(methacrylate)/purple membrane lamellar nanocomposite films by intercalation and in situ polymerisationcitations
- 2007Effects of single SNPs, haplotypes, and whole-genome LD maps on accuracy of association mappingcitations
- 2007Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene regioncitations
- 2005The optimal measure of linkage disequilibrium reduces error in association mapping of affection statuscitations
- 2005Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung functioncitations
- 2003Haplotypic analysis of the MMP-9 gene in relation to coronary artery diseasecitations
- 2003Positional cloning by linkage disequilibriumcitations
- 2002Mapping quantitative effects of oligogenes by allelic associationcitations
Places of action
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article
Mapping quantitative effects of oligogenes by allelic association
Abstract
Regression analysis of a quantitative trait as a function of a single diallelic polymorphism has been extended to allelic association by composite likelihood under the Malecot model for multiple markers. We applied the method to 10 single nucleotide polymorphisms (SNPs) spanning 27 kb of the angiotensin-I converting enzyme (ACE) gene in British families, localising a causal SNP between G2530A and 4656(CT)3/2 in the 3' region, at a distance of 21.6±0.9 kb from the most proximal SNP T-5491C. Neither they nor the I/D polymorphism is causal. To clarify genetic parameters we applied combined segregation, linkage and association analysis. Stronger evidence for the 3' region was obtained, with significant evidence of a lesser 5' effect as reported in French and Nigerian families. However, rigorous confirmation requires that the causal SNPs be identified. Both Malecot and parametric analysis appear to have high power by comparison with alternative methods for localizing oligogenes and their causal polymorphisms.