| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gradzielski, Michael
Technische Universität Berlin
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2024Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases.citations
- 2024Dynamic Covalent Amphiphilic Polymer Conetworks Based on End-Linked Pluronic F108: Preparation, Characterization, and Evaluation as Matrices for Gel Polymer Electrolytes
- 2024How Chromophore Labels Shape the Structure and Dynamics of a Peptide Hydrogel
- 2023Aggregation Behavior of Nonsymmetrically End-Capped Thermoresponsive Block Copolymers in Aqueous Solutions: Between Polymer Coils and Micellar States
- 2023Amphiphilic Polymer Conetworks Studied by SANS: Effect of the Type of Solubilizate and Molecular Architecture on the Swollen Gel Structure
- 2023Rheological Control of Aqueous Dispersions by Thermoresponsive BAB* Copolymers of Different Architecturescitations
- 2022Aggregation Behavior of Nonsymmetrically End-Capped Thermoresponsive Block Copolymers in Aqueous Solutions: Between Polymer Coils and Micellar Statescitations
- 2022Aggregation Behavior of Nonsymmetrically End-Capped Thermoresponsive Block Copolymers in Aqueous Solutions: Between Polymer Coils and Micellar Statescitations
- 2022Aggregation behavior of nonsymmetrically end-capped thermoresponsive block copolymers in aqueous solutionscitations
- 2021Effect of the supramolecular interactions on the nanostructure of halloysite/biopolymer hybrids: a comprehensive study by SANS, fluorescence correlation spectroscopy and electric birefringence
- 2020Structural control of polyelectrolyte/microemulsion droplet complexes (PEMECs) with different polyacrylates
- 2019Physicochemical stimuli as tuning parameters to modulate the structure and stability of nanostructured lipid carriers and release kinetics of encapsulated antileprosy drugscitations
- 2019Structural control of polyelectrolyte/microemulsion droplet complexes (PEMECs) with different polyacrylatescitations
- 2018Preparation of Polymer Brush Grafted Anionic or Cationic Silica Nanoparticles: Systematic Variation of the Polymer Shellcitations
- 2015Structure of reverse microemulsion-templated metal hexacyanoferrate nanoparticles
- 2013Temperature-regulated fluorescence and association of an Oligo(ethyleneglycol)methacrylate-based copolymer with a conjugated Polyelectrolyte-the effect of solution ionic strengthcitations
- 2012Structure of reverse microemulsion-templated metal hexacyanoferrate nanoparticles
- 2012Structure of reverse microemulsion-templated metal hexacyanoferrate nanoparticlescitations
- 2012Structure and dynamics of networks in mixtures of hydrophobically modified telechelic multiarm polymers and oil in water microemulsionscitations
- 2012Synthesis of Core-Shell Gold Nanoparticles with Maltose-Modified Poly(Ethyleneimine)citations
- 2010Amphiphilic dual brush block copolymers as "giant surfactants" and their aqueous self-assemblycitations
- 2008Evolution of ZnS Nanoparticles via Facile CTAB Aqueous Micellar Solution Route: A Study on Controlling Parameters
Places of action
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article
Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases.
Abstract
Increased disulfide crosslinking of secreted mucins causes elevated viscoelasticity of mucus and is a key determinant of mucus dysfunction in patients with cystic fibrosis (CF) and other muco-obstructive lung diseases. In this study, we describe the synthesis of a novel thiol-containing, sulfated dendritic polyglycerol (dPGS-SH), designed to chemically reduce these abnormal crosslinks, which we demonstrate with mucolytic activity assays in sputum from patients with CF. This mucolytic polymer, which is based on a reportedly anti-inflammatory polysulfate scaffold, additionally carries multiple thiol groups for mucolytic activity and can be produced on a gram-scale. After a physicochemical compound characterization, we compare the mucolytic activity of dPGS-SH to the clinically approved N -acetylcysteine (NAC) using western blot studies and investigate the effect of dPGS-SH on the viscoelastic properties of sputum samples from CF patients by oscillatory rheology. We show that dPGS-SH is more effective than NAC in reducing multimer intensity of the secreted mucins MUC5B and MUC5AC and demonstrate significant mucolytic activity by rheology. In addition, we provide data for dPGS-SH demonstrating a high compound stability, low cytotoxicity, and superior reaction kinetics over NAC at different pH levels. Our data support further development of the novel reducing polymer system dPGS-SH as a potential mucolytic to improve mucus function and clearance in patients with CF as well as other muco-obstructive lung diseases.