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Majecka, Agata
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article
Dendrimersomes: Biomedical applications
Abstract
In recent years, dendrimer-based vesicles, known as dendrimersomes, have garnered significant attentionas highly promising alternatives to lipid vesicles in a variety of biomedical applications. Dendrimersomesoffer several advantages, including relatively straightforward synthesis, non-immunogenic properties,stability in circulation, and minimal size variability. These vesicles are composed of Janus dendrimers,which are polymers characterized by two dendritic wedges with different terminal groups – hydrophilicand hydrophobic. This dendrimer structure enables the self-assembly of dendrimersomes. The purpose ofthis highlight is to provide an overview of recent advancements achieved through the utilization ofbiomimetic dendrimersomes in various biomedical applications such as drug and nucleic acid delivery.