| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rodrigues, João
Universidade da Madeira
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2024Epidemiological and clinical trends of visceral leishmaniasis in Portugal: retrospective analysis of cases diagnosed in public hospitals between 2010 and 2020citations
- 2023Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Studycitations
- 2023Experimental characterization of the nonlinear thermomechanical behaviour of refractory masonry with dry jointscitations
- 2023Target-Specific Delivery and Bioavailability of Pharmaceuticals via Janus and Dendrimer Particlescitations
- 2023Carbon dots and dendrimers nanohybrids: from synthesis to applicationscitations
- 2022Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocompositescitations
- 2022New insights into ruthenium(ii) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behaviourcitations
- 2022Dendrimers and dendrimersomes as a novel tool for effective drug delivery applicationscitations
- 2022Strain-modulated optical response in 2D MoSe2 made by Na-assisted CVD on glasscitations
- 2021Use of Half-Generation PAMAM Dendrimers (G0.5-G3.5) with Carboxylate End-Groups to Improve the DACHPtCl(2) and 5-FU Efficacy as Anticancer Drugscitations
- 2021Efficient reSe2 photodetectors with CVD single-crystal graphene contactscitations
- 2021Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulosecitations
- 2020A Review on Thermoplastic or Thermosetting Polymeric Matrices Used in Polymeric Composites Manufactured with Banana Fibers from the Pseudostemcitations
- 2019Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2)citations
- 2018Mechanical Properties of Alumina Nanofilled Polymeric Composites Cured with DDSA and MNAcitations
- 2018Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cellscitations
- 2018Recent therapeutic applications of the theranostic principle with dendrimers in oncologycitations
- 2017The influence of curing agents in the impact properties of epoxy resin nanocompositescitations
- 2016Effect of irregular shaped nanoalumina on the enhancement of mechanical properties of epoxy resin nanocomposites using DDM as hardenercitations
- 2015Octadecyl functionalized core-shell magnetic silica nanoparticle as a powerful nanocomposite sorbent to extract urinary volatile organic metabolitescitations
- 2015PAMAM Dendrimer/pDNA Functionalized-Magnetic Iron Oxide Nanoparticles for Gene Deliverycitations
- 2012The Effect of PAMAM Dendrimers on Mesenchymal Stem Cell Viability and Differentiationcitations
- 2012Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applicationscitations
- 2011ChemInform Abstract: Poly(alkylidenamines) Dendrimers as Scaffolds for the Preparation of Low‐Generation Ruthenium Based Metallodendrimers
- 2008Visible-light photolytic synthesis of multinuclear and dendritic iron-nitrile cationic complexes
Places of action
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article
New insights into ruthenium(ii) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behaviour
Abstract
Dendrimers have been studied as promising materials for the delivery of anticancer drugs. In this work, low-generation (0-2) nitrile poly(alkylidenamine)-based dendrimers were explored as nanocarriers for the organometallic complex [Ru(eta(5)-C5H5)(PPh3)(2)](+) (RuCp+) and investigated for their anticancer action and involved mechanisms, which were evaluated both in vitro and in vivo. It was observed that their biological behaviour is generation dependent, where the highest generation metallodendrimer (G2Ru) was overall more effective than the other metallodendrimers. G2Ru was active against a set of six cancer cell lines, revealing its important selectivity for these cells (the IC50 values were about 4-fold lower than that for non-cancer cells). Importantly, the in vivo studies with G2Ru in an MCF-7 xenograft mouse model showed that it exhibited low systemic toxicity, low accumulation in the main organs of the mice, preferential accumulation in the tumour, and remarkable capacity to limit tumour growth. The in vitro and in vivo studies revealed that G2Ru caused high levels of cell necrosis and apoptosis. The in vitro cell death mechanism studies showed the capacity of G2Ru to induce mitochondrial depolarization and ROS production. Altogether, pre-clinical results indicated G2Ru as a promising anticancer drug and the potential of low-generation poly(alkylidenamine)-based dendrimers as drug nanocarriers.