• Alves, Lg
• Cerqueira, F.
• Waerenborgh, Jc
• Almada, S.
• Maia, Lb
• Vieira, Bjc
• Mira, Np
• Silva, Er

Abstract

New cyclam-based complexes of formulae [{H-2(4-CF3PhCH2)(2)Cyclam}FeCl2]Cl and [{H-2(4-CF3PhCH2)(2)Cyclam}Cu](CH3COO)(2)center dot 2H(2)O were synthesized, in very high yields, by the reaction of H-2(4-CF3PhCH2)(2)Cyclam with the corresponding metal salts in methanol. [{H-2(4-CF3PhCH2)(2)Cyclam}FeCl2]Cl was also prepared, quantitatively, in the solid state by mechanochemistry. The Mossbauer spectra of [{H-2(4-CF3PhCH2)(2)Cyclam}FeCl2]Cl show that the high-spin cis complex is the major product of both reactions. The EPR data of [{H-2(4-CF3PhCH2)(2)Cyclam}Cu](CH3COO)(2)center dot 2H(2)O are consistent with two distinct Cu2+ species, whose solid state molecular structures were determined by single crystal X-ray diffraction and correspond to complexes displaying octahedral and square-pyramidal geometries. The screening of the antifungal activity of both metal complexes revealed the higher activity of [{H-2(4-CF3PhCH2)(2)Cyclam}FeCl2]Cl to inhibit the growth of unicellular and multicellular fungal species with described pathogenic potential.

Topics

• impedance spectroscopy
• single crystal X-ray diffraction
• single crystal
• copper
• iron
• electron spin resonance spectroscopy
• chemical ionisation
• molecular structure