| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lotti, Nadia
European Commission
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2024Critical Cooling Rate of Fast-Crystallizing Polyesters: The Example of Poly(alkylene trans-1,4-cyclohexanedicarboxylate)citations
- 2024Melting Behavior of Compression Molded Poly(ester amide) from 2,5-Furandicarboxylic Acid
- 2023Novel Nanostructured Scaffolds of Poly(butylene trans-1,4-cyclohexanedicarboxylate)-Based Copolymers with Tailored Hydrophilicity and Stiffness: Implication for Tissue Engineering Modelingcitations
- 2022Electrospun Membranes of Poly(butylene succinate) and Poly(butylene/2‐butyl,2‐ethyl‐propylene succinate)citations
- 2022Bio-based aliphatic/aromatic poly(trimethylene furanoate/sebacate) random copolymers:Correlation between mechanical, gas barrier performances and compostability and copolymer compositioncitations
- 2021Poly(butylene 2,4-furanoate), an Added Member to the Class of Smart Furan-Based Polyesters for Sustainable Packaging : Structural Isomerism as a Key to Tune the Final Propertiescitations
- 2020Ability of Trichoderma hamatum Isolated from Plastics-Polluted Environments to Attack Petroleum-Based, Synthetic Polymer Filmscitations
- 2020Broadband Dielectric Spectroscopy Study of Biobased Poly(alkylene 2,5-furanoate)s’ Molecular Dynamicscitations
- 2020Stability of crystal nuclei of poly (butylene isophthalate) formed near the glass transition temperature
- 2020Improving the flexibility and compostability of starch/poly(butylene cyclohexanedicarboxylate)-based blendscitations
- 2020Enthalpy relaxation, crystal nucleation and crystal growth of biobased poly(butylene isophthalate)citations
- 2020Broadband dielectric spectroscopy study of biobased poly(alkylene 2,5-furanoate)s’ molecular dynamicscitations
- 2018Influence of the nanofiber chemistry and orientation of biodegradable poly(butylene succinate)-based scaffolds on osteoblast differentiation for bone tissue regenerationcitations
- 2018Crystallization of isodimorphic aliphatic random copolyesters: Pseudo-eutectic behavior and double-crystalline materialscitations
- 2018Cold-crystallization of poly(butylene 2,6-naphthalate) following Ostwald's rule of stagescitations
- 2018Crystallization of isodimorphic aliphatic random copolyesters: pseudo-eutectic behavior and double-crystalline materialscitations
- 2018Characterization of Active Edible Films based on Citral Essential Oil, Alginate and Pectincitations
- 2017Novel Random PBS-Based Copolymers Containing Aliphatic Side Chains for Sustainable Flexible Food Packagingcitations
- 2014Poly(propylene terephthalate) containing 4,4-sulfonylbisphenol units:effect of chemical composition on the physical-chemical propertiescitations
- 2013Towards homogeneous dynamics in incompatible blends by selective transesterificationcitations
- 2010Structure and morphology of thin films of linear aliphatic polyesters prepared by spin-coatingcitations
Places of action
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article
Influence of the nanofiber chemistry and orientation of biodegradable poly(butylene succinate)-based scaffolds on osteoblast differentiation for bone tissue regeneration
Abstract
<p>Innovative nanofibrous scaffolds have attracted considerable attention in bone tissue engineering, due to their ability to mimic the hierarchical architecture of an extracellular matrix. Aiming at investigating how the polymer chemistry and fiber orientation of electrospun scaffolds (ES) based on poly(butylene succinate) (PBS) and poly(butylene succinate/diglycolate) (P(BS80BDG20)) affect human osteoblast differentiation, uniaxially aligned (a-) and randomly (r-) distributed nanofibers were produced. Although human osteoblastic SAOS-2 cells were shown to be viable and adherent onto all ES materials, a-P(BS80BDG20) exhibited the best performance both in terms of cellular phosphorylated focal adhesion kinase expression and in terms of alkaline phosphatase activity, calcified bone matrix deposition and quantitative gene expression of bone specific markers during differentiation. It has been hypothesized that the presence of ether linkages may lead to an increased density of hydrogen bond acceptors along the P(BS80BDG20) backbone, which, by interacting with cell membrane components, can in turn promote a better cell attachment on the copolymer mats with respect to the PBS homopolymer. Furthermore, although displaying the same chemical structure, r-P(BS80BDG20) scaffolds showed a reduced cell attachment and osteogenic differentiation in comparison with a-P(BS80BDG20), evidencing the importance of nanofiber alignment. Thus, the coupled action of polymer chemical structure and nanofiber alignment played a significant role in promoting the biological interaction.</p>