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| Petrov, R. H. | Madrid |
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| Azevedo, Nuno Monteiro |
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Sachot, Nadine
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article
A novel hybrid nanofibrous strategy to target progenitor cells for a cost-effective in situ angiogenesis
Abstract
Although the impact of composites based on Ti-doped calcium phosphate glasses is low compared withthat of bioglass, they have been already shown to possess great potential for bone tissue engineering.Composites made of polylactic acid (PLA) and a microparticle glass of 5TiO2–44.5CaO–44.5P2O5–6Na2O(G5) molar ratio have already demonstrated in situ osteo- and angiogenesis-triggering abilities. As many ofthe hybrid materials currently developed usually promote osteogenesis but still lack the ability to inducevascularization, a G5/PLA combination is a cost-effective option for obtaining new instructive scaffolds. Inthis study, nanostructured PLA-ORMOGLASS (organically modified glass) fibers were produced by electrospinning,in order to fabricate extra-cellular matrix (ECM)-like substrates that simultaneously promote boneformation and vascularization. Physical–chemical and surface characterization and tensile tests demonstratedthat the obtained scaffolds exhibited homogeneous morphology, higher hydrophilicity andenhanced mechanical properties than pure PLA. In vitro assays with rat mesenchymal stem cells (rMSCs)and rat endothelial progenitor cells (rEPCs) also showed that rMSCs attached and proliferated on thematerials influenced by the calcium content in the environment. In vivo assays showed that hybrid compositePLA-ORMOGLASS fibers were able to promote the formation of blood vessels. Thus, these novel fibers are avalid option for the design of functional materials for tissue engineering applications.